TABLE 2

Randomized, controlled studies evaluating nitrate supplementation on blood pressure in hypertensive patients

ReferenceCohortDesignInterventionTreatment DurationBaseline BP (mm Hg)Max ΔBP (mm Hg)
Ghosh et al., 2013Uncontrolled HTNCrossoverBeetroot juice, 3.3 mmol nitrate1 day140/86−8.5/N.S.
Age = 53n = 15Matched-volume water control
Kapil et al., 2015Uncontrolled HTNParallelBeetroot juice, 6.4 mmol nitrate4 wkClinic 138/84Clinic −8/−2
Age = 57n = 64Nitrate-deplete beetroot juice placeboHome 139/82Home −8/−4
ABP 139/82Abp −8/−5
Bondonno et al., 2015bControlled HTNCrossoverBeetroot juice, 7 mmol nitrate1 wk133/76N.S.
Age = 63n = 30Nitrate-deplete beetroot juice placebo
Kerley et al., 2018Uncontrolled HTNCrossoverBeetroot juice, 12.9 mmol nitrate1 wkABP 137/80−8/−4
Age = 63n = 20Nitrate-deplete beetroot juice placebo
Broxterman et al., 2019Controlled HTNCrossoverBeetroot juice, 6.2 mmol nitrate3 days132/78N.S.
Age = 53n = 13Nitrate-deplete beetroot juice placebo
Broxterman et al., 2019Uncontrolled HTNCrossoverBeetroot juice, 6.2 mmol nitrate3 days141/88−5/−4
Age = 49n = 14Nitrate-deplete beetroot juice placebo
Zafeiridis et al., 2019Uncontrolled HTNCrossoverBeetroot juice, 8.1 mmol nitrate2.5 h144/95−6/−2
Age = 44n = 18Nitrate-deplete beetroot juice placebo
  • HTN, hypertensive patients.