TABLE 1

Potential devices and candidate digital endpoints for use in clinical trials outside of clinical units

Device/SensorCandidate EndpointPatient Domain
AccelerometerPhysical activityMobility
StepsSymptom severity
Gait patternsSymptom severity
Tremor analysisSymptom severity
Blood-pressure meterBlood pressureCardiovascular health
CameraDermatological assessmentsDermatological health
Treatment adherenceCompliance
DynamometerMuscle strengthMusculoskeletal health
ECGEvent detectionCardiovascular health
Glucose monitorGlucoseDiabetic control
OximeterOxygen saturationPulmonary healthy
GPSGPS mobilityMobility
Location typeSocial behavior
Light sensorLight intensityEnvironment
MicrophoneEvent detectionClinical events
Voice analysisMood
PPGHeart rateCardiovascular health
SmartphoneApp useSocial behavior
Phone use (calls, sms)Symptom severity
Patient reported outcomesSymptom severity
SpirometerPulmonary functionPulmonary health
ThermometerTemperatureInfection control
Thermoregulation
Touch screenResponse timeDexterity
Speed of typingCoordination
Custom testsVarious
  • PPG, photoplethysmography.