TABLE 1

Signal-transduction mechanisms of EP1–4 and IP receptor subtypes

References for this table could be found in I. Introduction section and in Breyer et al. (2019)

ReceptorPrimary G-ProteinClassic Second MessengerOther G-Protein
EP1GqIntracellular Ca2+Gi, G12/13
EP2GscAMP
EP3GicAMPGq, Gs, G12
EP4GscAMPGi
IPGscAMPGi, Gq