Main Points

•Extended data base mining to identify LoF-intolerant GPCRs
•Explore pathologic potential of variations in noncoding genic components of GPCR genes (promoter, introns, UTR)
•Explore pathologic potential of neglected GPCRs (e.g., ecnomotopic odorant and taste receptors)
•Improve structural and evolutional approaches to predict the functional relevance of GPCR variations
•Extended use of genome editing methods in research and therapy