Main Points
| •Extended data base mining to identify LoF-intolerant GPCRs |
| •Explore pathologic potential of variations in noncoding genic components of GPCR genes (promoter, introns, UTR) |
| •Explore pathologic potential of neglected GPCRs (e.g., ecnomotopic odorant and taste receptors) |
| •Improve structural and evolutional approaches to predict the functional relevance of GPCR variations |
| •Extended use of genome editing methods in research and therapy |