NaB effects on cocaine, alcohol, opiate, methamphetamine, amphetamine, and nicotine reward and relapse
| Reference | Drug of Abuse | Addiction Model | HDAC Inhibitor and Dose | Treatment Duration | Outcome | HDAC Measured | Gut Microbiome Mentioned or Assessed |
|---|---|---|---|---|---|---|---|
| Sun et al. (2008) | Cocaine | S/A | NaB 100, 200, 400 mg/kg | 12 h before coc test | Low doses no effect. Highest dose ↑ S/A | No | No |
| Schroeder et al. (2008) | Cocaine | CPP | NaB 25 or 100 mg/kg | 1/Day for 10 days | NaB ↑ effects of DA D1R agonist on locomotor; NaB did not enhance DA D1R effect on CPP | Yes | No |
| Romieu et al. (2008) | Cocaine | S/A | Phenylbutyrate 20 or 100 mg/kg | 30 min before test | Phenylbutyrate ↓ S/A and ↓ breaking point | No | No |
| Sanchis-Segura et al. (2009) | Cocaine | LS | NaB 100, 150, 300 mg/kg | 20 min before test | NaB ↑ LS | Yes | No |
| Malvaez et al. (2010) | Cocaine | CPP | NaB 1200 mg/kg | During EXT | NaB ↑ CPP EXT; ↓ REL of extinguished CPP | Yes | No |
| Romieu et al. (2011) | Cocaine | S/A | Phenylbutyrate 20 or 100 mg/kg | 1/Day for 5 days | Phenylbutyrate ↓ in S/A | No | No |
| Raybuck et al. (2013) | Cocaine | CPP | NaB 300, 600, 1200 mg/kg | 24 h after conditioning | Highest dose ↑ ACQ of CPP; low dose ↑ EXT; high dose ↓ EXT | Yes | No |
| Sanchis-Segura et al. (2009) | Alcohol | LS | NaB 100, 150, 300 mg/kg | 20 min before test | NaB ↑ LS; does not block TOL to locomotor effects | Yes | No |
| Xu et al. (2012) | Alcohol | CPP | NaB 200 mg/kg, 4/day for 15 days | Prior to entering chamber | NaB ↑ ACQ of CPP | Yes | No |
| Legastelois et al. (2013) | Alcohol | LS | NaB 200 or 600 mg/kg | 1/Day before alcohol after 30 min, then into LS chamber | NaB ↓ LS, depends on alcohol dose; both 1 and 2 g/kg ↑ LS but NaB only ↓ alcohol dose of 1 g/kg | Yes | No |
| Simon-O’Brien et al. (2015) | Alcohol | S/A | NaB 600 mg/kg, MS-275 10 mg/kg | 30 min before alcohol drinking test | Both ↓ AD in dependent rats, prevented escalation to excessive drinking | Yes | No |
| Sanchis-Segura et al. (2009) | Morphine | LS and CPP | NaB 100, 150, 300 mg/kg | 20 min before testing | NaB ↑ LS; NaB ↑ CPP | Yes | No |
| Wang et al. (2010) | Morphine | CPP | NaB 1200 mg/kg | NaB ↑ CPP EXT; NaB ↓ REL | No | No | |
| Jing et al. (2011) | Morphine | LS | NaB 40, 80, 160 mg/kg VAL 37.5, 75, 150 mg/kg | 1/Day for 3 days 20 min before testing | NaB and VAL ↓ LS | No | No |
| Chen et al. (2016) | Heroin | S/A | NaB 200, 400 mg/kg | 6 h and 12 h before testing | NaB did not alter S/A; NaB ↑ REL of S/A | Yes | No |
| Perreau-Lenz et al. (2017) | Morphine | LS and CPP in Per1 KO mice (clock gene) | NaB 150 mg/kg | Prior to testing | Per1 KO mice show ↓ of LS and CPP; NaB ↑ LS and CPP in Per1 KO mice | Yes | No |
| Harkness et al. (2013) | Methamphetamine | LS | NaB 630 mg/kg | 30 min prior to each methamphetamine injection | NaB ↑ locomotor response in untreated and sensitized animals; NaB ↑ LS | Yes | No |
| Zhu et al. (2017) | Methamphetamine | CPP | NaB 400 mg/kg | 30 min before methamphetamine | NaB ↑ ACQ of CPP; NaB ↑ EXT of CPP; NaB ↓ REL of CPP | No | No |
| Coccurello et al. (2007) | Methamphetamine | LS | VAL 150 mg/kg | 20 min before methamphetamine | VAL ↓ LS | No | No |
| Kalda et al. (2007) | Amphetamine | LS | NaB 630 mg/kg, VAL 175 mg/kg | 15 min before amphetamine for 6 days | NaB and VAL ↓ LS | Yes | No |
| Shen et al. (2008) | Amphetamine | LS | NaB 630 mg/kg, VAL 175 mg/kg | 15 min before amphetamine | NaB and VAL ↑ LS | Yes | No |
| Pastor et al. (2011) | Nicotine | CPP | Phenylbutyrate 100 mg/kg | 30 min prior to nicotine | Phenylbutyrate ↓ CPP | Yes | No |
| Castino et al. (2015) | Nicotine | S/A | NaB 100 mg/kg | Immediately or 6 h after EXT sessions | NaB immediate ↓ REL | No | No |
↓, decreases; ↑, increases; ACQ, acquisition; AD, alcohol drinking; coc, cocaine; EXT, extinction; KO, knockout; LS, locomotor sensitization; min, minutes; REL, relapse/reinstatement; S/A, self-administration; TOL, tolerance; VAL, valproic acid.