Reference | Drug of Abuse | Addiction Model | Antibiotic and Dose | Ab Treatment Duration | Outcome | GLT1/Glia Measured | Gut Microbiome Mentioned or Assessed |
---|---|---|---|---|---|---|---|
Rawls et al. (2010a) | Morphine | MD | CTX 50, 100, 150, 200 mg/kg | 2 Days before MOR and with MOR for another 10 days | CTX (150 and 200 mg/kg) ↓ induced WD | No | No |
Rawls et al. (2010b) | Morphine | Analgesic TOL | CTX 25, 50, 100 mg/kg | 3 Days before MOR and with MOR for another 7 days | CTX (50 and 100 mg/kg) ↓ development of analgesic TOL | No | No |
Chen et al. (2012) | Morphine | Hyperalgesia | CTX 200 mg/kg | 3 Days before MOR and with MOR for another 4 days | CTX ↓ hyperalgesia | Yes | No |
Fan et al. (2012) | Morphine | CPP | CTX 25 mg/kg | Before MOR on each day | CTX alone did not alter any facet of CPP; CTX + MK-801 (NMDAR antagonist) reduced ACQ of CPP and ↓ REL to CPP | No | No |
Shen et al. (2014) | Heroin | S/A | CTX 200 mg/kg | Start on day 8 of EXT and for 7 days more | CTX ↓ cue-induced REL | No but confirmed with electrophys | No |
Habibi-Asl et al. (2014) | Morphine | MD and TOL | CTX 50, 100, 200 mg/kg | 4 Days before MOR | CTX ↓ analgesic TOL and ↓ naloxone WD | No | |
Schroeder et al. (2014) | Morphine | CPP, hyperthermia, LS | CTX 200 mg/kg, CLV 10 mg/kg | 3 Days before and through conditioning | CTX and CLV ↓ CPP, hyperthermia, and LS | No | No |
Alshehri et al. (2018) | Hydrocodone | CPP in ALC-P rats | CTX 200 mg/kg | CTX every other day for days 14–21 in EXT | CTX ↓ REL | Yes | No |
Mehri et al. (2018) | Morphine | CPP | CLV 1, 50, 150 mg/kg | With MOR 4 days in conditioning phase | CLV (50 and 150 mg/kg) ↓ ACQ of CPP and ↓ REL | No | No |
Hutchinson et al. (2008) | Morphine | Respiratory depression, CPP | MINO 25 or 50 mg/kg 30 min before MOR | Before MOR and throughout | MINO 50 mg/kg ↓ CPP | No/no | No |
Zhang et al. (2015) | Morphine | Analgesic TOL in rats with spinal nerve ligation | MINO 30 mg/kg | Start at day 7 for 3 days before MOR | MINO ↓ development of TOL | No/no | No |
Arezoomandan and Haghparast (2016) | Morphine | CPP | MINO 1, 5, 10 ug into NAc each of 7 days of EXT | Before MOR on each of 7 days of EXT | MINO ↑ EXT of CPP and ↓ REL | No/no | No |
↓, decreases; ↑, increases; Ab, antibiotic; ACQ, acquisition; ALC-P, alcohol-preferring rats; electrophys, electrophysiology; EXT, extinction; LS, locomotor sensitization; MD, morphine dependence; MOR, morphine; NMDAR, NMDA receptor; REL, relapse/reinstatement; S/A, self-administration; TOL, tolerance; WD, withdrawal.