Ontogeny profile of hepatic phase I enzymes in cynomolgus monkey based on mRNA expression levels
Percentages represent expression/activity relative to adult levels.
| Onset of Activity and/or Expression | Adult Levels Reached | Age-Related Changes in Activity/Expression | Comments | References | ||
|---|---|---|---|---|---|---|
| CYP1A1 | ||||||
| mRNA expression | F: −74 days (3.6%) | NR (156% at 183 days) | Inconsistent pattern/increased rapidly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP2A23 | ||||||
| mRNA expression | F: −74 days (1.3%) | NR (130% at 365 days) | Increased rapidly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP2A24 | ||||||
| mRNA expression | F: −74 days (2%) | NR (118% at 365 days) | Increased rapidly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP2B6 | ||||||
| mRNA expression | F: −74 days (0.3%) | NR (183% at 365 days) | Increased slowly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP2C8 | ||||||
| mRNA expression | F: −74 days (32%) | NR (75% at 365 days) | Inconsistent pattern | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP2C9 | ||||||
| mRNA expression | F: −74 days (0.2%) | 183 days | Increased rapidly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP2C18 | ||||||
| mRNA expression | F: −74 days (14%) | NR (38% at 365 days) | Increased slowly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP2C19 | ||||||
| mRNA expression | F: −74 days (0.2%) | NR (75% at 548 days) | Increased rapidly/increased progressively | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP2C76 | ||||||
| mRNA expression | F: −74 days (0.3%) | NR (70% at 548 days) | Increased rapidly/increased progressively | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP2D17 | ||||||
| mRNA expression | F: −74 days (0.5%) | 183 days | Increased rapidly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP2E1 | ||||||
| mRNA expression | F: −74 days (0.07%) | NR (46% at 548 days) | Increased rapidly/increased progressively | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP2J2 | ||||||
| mRNA expression | F: −74 days (20%) | NR (81% at 183 days) | Nonlinear pattern/increased rapidly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP3A4 | ||||||
| mRNA expression | F: −74 days (0.2%) | NR (68% at 30 days) | Increased rapidly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP3A5 | ||||||
| mRNA expression | F: −74 days (0.2%) | 30 days | Inconsistent pattern | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP3A43 | ||||||
| mRNA expression | F: −74 days (149%) | −74 days | No changes/inconsistent pattern | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP4A11 | ||||||
| mRNA expression | F: −74 days (21%) | NR (216% at 30 days) | Inconsistent pattern/increased rapidly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP4F3 | ||||||
| mRNA expression | F: −74 days (11%) | NR (152% at 183 days) | Inconsistent pattern/increased rapidly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP4F11 | ||||||
| mRNA expression | F: −74 days (15%) | NR (230% at 183 days) | Inconsistent pattern/increased rapidly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP4F12 | ||||||
| mRNA expression | F: −74 days (52%) | −74–30 days | No changes (variable) | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
| CYP4F2 | ||||||
| mRNA expression | F: −74 days (10%) | 183 days | Increased rapidly | Single study, only M at 6 mo and 2 to 3 yr, only F at −74 days. Adult age: 2 to 3 yr. Fetal development: −74 days only F. Methods: DNA microarray. Strain: cynomolgus macaque (M/F) | Ise et al. (2011) | |
F, female; M, male; NR, not reported.