Biochemical effects implicating glutamatergic neurotransmission
Studies and experiments that did not identify an effect are not summarized in this table; please refer to the text for these details.
Compound | Concentration/Dose | Timing | Effect | System | References |
---|---|---|---|---|---|
BDNF | |||||
(2R,6R)-HNK | 10 mg/kg, i.p. | 24 h post-treatment | Increased BDNF protein levels | Mouse hippocampus | Zanos et al. (2016) |
10 mg/kg, i.p. | 30 min post-treatment | Increased BDNF protein levels | Mouse hippocampus | Lumsden et al. (2019) | |
10 and 50 nM | 1-h exposure | Increased BDNF release | Rat primary neurons | Fukumoto et al. (2019) | |
10–100 µM | 15-min exposure | Decreased TrkB/AP-2 interactions | MG87:TRKB cells | Fred et al. (2019) | |
(2S,6S)-HNK | 10 mg/kg, i.p. | 30–60 min post-treatment | Increased extracellular BDNF levels | Mouse prefrontal cortex | Anderzhanova et al. (2020) |
cAMP | |||||
(2R,6R)-HNK | 10 µM | 15-min exposure | Increased cAMP accumulation | C6 cells | Wray et al. (2019) |
eEF2 | |||||
(2R,6R)-HNK | 10 mg/kg, i.p. | 1 h post-treatment | Decreased eEF2 phosphorylation | Mouse hippocampus | Zanos et al. (2016) |
24 h post-treatment | |||||
50 µM | 30-min exposure | Decreased eEF2 phosphorylation | Mouse primary neurons | Suzuki et al. (2017) | |
mTOR and downstream pathways | |||||
(2R,6R)-HNK | 10 mg/kg, i.p. | 30 min post-treatment | Increased p-mTOR | Mouse hippocampus | Lumsden et al. (2019) |
30 mg/kg, i.p. | 30 min post-treatment | Increased p-mTOR | Mouse prefrontal cortex | Fukumoto et al. (2019) | |
1–50 nM | 1-h exposure | Increased pERK | Rat primary neurons | Fukumoto et al. (2019) | |
(2S,6S)-HNK | 20 mg/kg, i.v. | 20 min post-treatment | Increased p-mTOR | Rat prefrontal cortex | Paul et al. (2014) |
0.01–1 nM | 1-h exposure | PC-12 cells | |||
20 mg/kg, i.v. | 20–60 min post-treatment | Increased p4E-BP1 | Rat prefrontal cortex | Paul et al. (2014) | |
Increased pp70S6K | |||||
0.5 nM | 1-h exposure | Increased p4E-BP1 | PC-12 cells | Paul et al. (2014) | |
0.5–1 nM | 1-h exposure | Increased pERK | |||
0.1–1 nM | 1-h exposure | Increased pAkt |
pAkt, phosphorylated protein kinase B; p-MTOR, phosphorylated mTOR; pp70S6K, phosphorylated p70S6 kinase; p4E-BP1, phosphorylated eukaryotic initiation factor 4E-binding protein 1.