Changes in AMPAR expression
Studies and experiments that did not identify an effect are not summarized in this table; please refer to the text for these details.
| Compound | Effective Dose/Concentration | Timing | Effect | System | References |
|---|---|---|---|---|---|
| (2R,6R)-HNK | 10 mg/kg, i.p. | 24 h post-treatment | Increased GluA1 protein expression | Mouse hippocampus | Zanos et al. (2016) |
| Increased GluA2 protein expression | |||||
| 1–10 µM | 90-min exposure | Increased GluA1 surface protein expression | Rat primary neurons | Shaffer et al., (2019) | |
| 0.1–10 µM | 180-min exposure | ||||
| 200–400 nM | 24-h exposure | Increased GluA1 mRNA expression | U251-MG human glioblastoma cells | Ho et al. (2018) | |
| 400 nM | Increased GluA2 mRNA expression | ||||
| 400 nM | Increased GluA4 mRNA expression | ||||
| 400 nM | 24-h exposure | Increased GluA4 mRNA expression | Human iPSC-derived astrocytes | Ho et al. (2018) | |
| (2S,6S)-HNK | 200–400 nM | 24-h exposure | Increased GluA1 mRNA expression | U251-MG human glioblastoma cells | Ho et al. (2018) |
| 400 nM | Increased GluA2 mRNA expression | ||||
| 400 nM | Increased GluA4 mRNA expression | ||||
| 400 nM | 24-h exposure | Increased GluA1 mRNA expression | Human iPSC-derived astrocytes | Ho et al. (2018) | |
| 400 nM | Increased GluA2 mRNA expression | ||||
| 400 nM | Increased GluA4 mRNA expression |