TABLE 1
Structural alerts for constituents in select natural products
Reprinted with permission from the American Society for Pharmacology and Experimental Therapeutics from Johnson et al. (2018).
| Constituent(s)/Natural Product | Structural Alert | Alert Substructure |
|---|---|---|
| Flavonoids, phenylpropanoids/Echinacea glycyrrhizin, glycyrrhizinic acid/licorice | Catechols |  |
| Isoquinoline alkaloids/goldenseal terpenoids/cinnamon curcuminoids/turmeric | Masked catechol |  ,  |
| Isoquinoline alkaloids/goldenseal shizandrins/Schisandra spp. Gomisins/Schisandra spp. | Methylenedioxyphenyl |  |
| Cycloartenol/black cohosh | Subterminal olefin |  |
| Polyacetylenes/Echinacea | Terminal and subterminal acetylenes |  ,  |
| Terpenoids/cinnamon diallyl disulfides and trisulfides/garlic | Terminal olefin |  |
| Cinnamaldehyde/cinnamon | α,β-Unsaturated aldehyde |  |
| Curcuminoids/turmeric | α,β-Unsaturated ketone |  |