TABLE 3

Summary of biotech and big pharma exploring NLRP3 as a target

CompanyTargetEntityDevelopment StatusWebsite
OlatecNLRP3Small-molecule inhibitorsPhase IIolatec.com
Inflazome/RocheNLRP3Small-molecule inhibitorsPhase Ibroche.com
NovartisNLRP3Small-molecule inhibitor acquired from IFM TrePhase Inovartis.com
GenentechNLRP3Small-molecule inhibitors acquired from Jecure therapeuticsPreclinicalgene.com
NodTheraNLRP3Small-molecule inhibitorsPreclinicalwww.nodthera.com
Quench BioGasdermin-DSmall-molecule inhibitorsPreclinicalquenchbio.com
ZyVersa TherapeuticsASCNeutralizing antibodyPreclinicalwww.zyversa.com
Ardan ImmunoPharmaTMEM176BSmall-molecule inhibitors and activatorsPreclinicalardan-pharma.com