| µg/kg | | | | |
Rolipram | 300 | — | Intraperitoneal | Mouse | Xylazine/ketamine/anesthesia test | Vanmierlo et al., 2016 |
Roflumilast | 3000 | 10 | | | | |
R-rolipram | 100 | — | Subcutaneous | Mouse | Xylazine/ketamine/anesthesia test | Robichaud et al., 2002b |
S-rolipram | 1000 | 10 | | | | |
PMNPQ | 1 | 0.01 | | | | |
CT-2450 | >30,000 | >300 | | | | |
Rolipram | 100 | — | Intravenous | Mouse | Xylazine/ketamine/anesthesia test | Burgin et al., 2010 |
D157140 | 10 | 0.1 | | | | |
D158681 | >1000 | >10 | | | | |
D159153 | 100 | 1 | | | | |
D159382 | 30 | 0.3 | | | | |
D159404 | >3000 | >30 | | | | |
D159687 | >3000 | >30 | | | | |
Rolipram | 30 | — | Subcutaneous | Mouse | Xylazine/ketamine/anesthesia test | Ricciarelli et al., 2017 |
GEBR32a | >3000 | >30 | | | | |
Rolipram | 30 | — | Subcutaneous | Mouse | Xylazine/ketamine/anesthesia test | Bruno et al., 2011 |
GEBR7b | 300 | 10 | | | | |
Rolipram | 500 | — | Intragastric | Mouse | Xylazine/ketamine/anesthesia test | Zhou et al., 2017 |
10j | >1500 | >3 | | | | |
Rolipram | 800 | — | Oral | Dog | Emesis incidence | Zhou et al., 2017 |
10j | >800 | >1 | | | | |
Rolipram | 400 | — | Oral | Rat | Pica feeding | Davis et al., 2009 |
Roflumilast | 1570 | >3.5 | | | | |
Cilomilast | 6410 | >16 | | | | |
EPPA-1 | 24,260 | >60 | | | | |
Rolipram | 500 | — | Oral | Dog | Emesis incidence | Zhang et al., 2013 |
Chlorbipram | >1000 | >2 | | | | |
Chlorbipram hydrochloride | >1070 | >2 | | | | |
Rolipram | <100 | — | Oral | Dog | Emesis incidence | Nose et al., 2016 |
Roflumilast | 500 | >5 | | | | |
GPD-1116 | 1000 | >10 | | | | |
Rolipram | 3000 | — | Oral | Ferret | Emesis incidence | Aoki et al., 2001b |
YM976 | 30,000 | 10 | | | | |
RP73401 | 3000 | 1 | | | | |
CPP840 | 30,000 | 10 | | | | |
Rolipram | 10,000 | — | Oral | Ferret | Emesis incidence | Gale et al., 2003 |
V11294 | >30,000 | >3 | | | | |
Rolipram | 40 | — | Intraperitoneal | Mouse | Acute gastric retention measurement | McDonough et al., 2020a |
Piclamilast | 200 | 5 | | | | |
YM976 | 1000 | 25 | | | | |