TABLE 2

α7 PAMs (see Figure 4 for select structures)

PAMChemical NameTypeReference
5-HI5-HydroxyindoleI(Zwart et al., 2002)
CCMIN-(4-Chlorophenyl)-α-[[(4-chloro-phenyl)amino]methylene]-3-methyl-5-isoxazoleacet-amideI(Ng et al., 2007)
NS-17381-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-ureaI(Timmermann et al., 2007)
PNU-1205961-(5-Chloro-2,4-dimethoxy-phenyl)-3-(5-methyl-isoxazol-3-yl)-ureaII(Hurst et al., 2005)
TQS4-Naphthalene-1-yl-3a,4,5,9b-tetrahydro-3-H-cyclopenta[c]quinoline-8-sulfonic acid amideII(Gronlien et al., 2007)
A-8677444-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamideII(Faghih et al., 2009)
SB-2065533,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamideII(Dunlop et al., 2009)
JNJ-19309422-[[4-Fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanolII(Dinklo et al., 2011)
Genestein5,7-Dihydroxy-3-(4-hydroxyphenyl)chromen-4-oneI(Gronlien et al., 2007)
Ivermectin22,23-Dihydroavermectin B1a + 22,23-dihydroavermectin B1bI(Collins and Millar, 2010)
LL-000664714-(5-(4-Chlorophenyl)-2-(2-cyclopropylacetyl)-l, 4-dimethyl-lh-pyrrol-3-yl)benzenesulfonamideN.D.(Verma et al., 2021)
PAM-2(E)-3-furan-2-yl-N-p-tolyl-acrylamideII(Targowska-Duda et al., 2019)
BNC3754-((1R,3R)-3-(((5-Chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)benzenesulfonamideI(Harvey et al., 2019)
Compound 284-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamideN.D.(Sinha et al., 2020)
RGM0791-(2',5′-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanoneII(Perez de Vega et al., 2019)
JWX-A01086-(2-Chloro-6-methylphenyl)-2-((3-fluoro-4-methylphenyl)amino)thiazolo[4,5-d]pyrimidin-7(6H)-oneI(Sun et al., 2019)
AVL-3288N‐(4‐Chlorophenyl)‐α‐[[(4‐chloro‐phenyl)amino]methylene]‐3‐methyl‐5‐isoxazoleacet‐amideI(Thomsen and Mikkelsen, 2012b)
B-9733-(3,4-Difluorophenyl)-N-(1-(6-(4-(pyridin-2-yl)piperazin-1-yl)pyrazin-2-yl)ethyl)propanamideII(Post-Munson et al., 2017)
Compound 1112,4,2′,5′-TetrahydroxychalconeII(Balsera et al., 2014)
RO51269465-Chloro-N-[(1S,3R)-2,2-dimethyl-3-(4-sulfamoyl-phenyl)-cyclopropyl]-2-methoxy-benzamideI(Sahdeo et al., 2014)
Lu AF58801(1S,2S)-2-Phenyl-cyclopropanecarboxylic acid [α(R)-(4-ethoxy-phenyl)-2-hydroxy-ethyl]-amideI(Eskildsen et al., 2014)

N.D., not determined.