TABLE 2

Critical drug product attributes: inhaled drugs for treatment of respiratory diseases

AttributeFunctionTypical MethodReferences
Dose deliveredControl body burden doseFilterOlsson et al. (2021)
Dose deposition patternControl therapeutic dose
Control local and systemic exposure
Impactor stage deposition (APSD)Olsson et al. (2021)
Device specification (flow and
patient handling)
Dose release rateControl local and systemic exposureDissolution testAmini and Hochhaus (2021)
Formulation specification (impact on
dissolution and permeation)