TABLE 2

Levels of angiotensin metabolites in kidney and blood in various rat strains

SD(mRen2)27SDSHR(mRen2)27
n = 6
mean ± S.E.M.
n = 8
mean ± S.E.M.
n = 6–8
mean (IQL range)
n = 8
mean ± S.D.
n = 5–8
mean ± S.E.M.
Kidney (fmol/g)
Ang-(1-10)234 ± 3320 ± 2564 (313–907)413 ± 139163 ± 69
Ang-(1-8)338 ± 33474 ± 40729 (431–1892)431 ± 44388 ± 36
Ang-(1-7)33 ± 8ND173 (65–279)66 ± 4520 ± 3
Ang-(1-5)NDND17 (<13–40)16 ± 613 ± 4
Ang-(2-8)<15ND75 (44–121)<826 ± 3
Ang-(3-8)NDND<10ND5 ± 0
Ang-(2-10)37 ± 5NDNDND30 ± 15
Ang-(1-9)113 ± 19NDNDND42 ± 12
Blood (fmol/ml)
Ang-(1-10)100 ± 3578 ± 5141 (103–200)375 ± 196ND
Ang-(1-8)47 ± 15125 ± 9105 (75–141)36 ± 36ND
Ang-(1-7)5 ± 213 ± 1<8<7ND
Ang-(1-5)NDND5 (3–6)2 ± 1ND
Ang-(2-8)29 ± 8ND4 (<2.5–6)<3ND
Ang-(3-8)NDND4 (3–6)4 ± 6ND
Ang-(2-10)34 ± 12NDNDNDND
Ang-(1-9)<1NDNDNDND
  • IQL, interquartile; m(Ren2)27, transgenic rat overexpressing mouse Ren2 gene; ND, not done; SD, Sprague Dawley.

  • Data are from Campbell et al. (1991, 1995b); Roksnoer et al. (2015); and Uijl et al. (2019, 2021) and have been determined either by radioimmunoassay after high-performance liquid chromatography separation (first two columns) or by using liquid chromatography-tandem mass-spectrometry (last three columns).