Comparison of ADC and ADCN features
| ADC | ADCN | |
|---|---|---|
| Antibody requirement | A single antibody is used to bind one target | Multiple antibodies can be added to target heterogeneous and/or drug resistant tumors |
| Linker influence | Linkers affect payload potency and can cause side effects, especially with cleavable linkers | Target binding and payload are not affected by linkers |
| Payload requirement | Highly potent drugs are needed | Drugs with lower potency can be used |
| DAR | Has a limited DAR range (1–8) | Higher amount of drug can be encapsulated (can reach >100) |
| Single/multiple-type payload | One type of payload is primarily used | Multiple types of payloads can be loaded |
| Receptor clustering | Regular receptor clustering (in classic, monospecific antibodies) | Potential for enhanced receptor clustering |
| Preparation | Precise chemical synthesis with multiple reaction steps | Mainly relies on self-assembly |