Summary of preclinical efficacy of group III mGlu receptor allosteric modulators in stress-related deficits
| Receptor | Type | Compound | Behavioral Effect | References |
|---|---|---|---|---|
| mGlu4 | PAM | PHCCC | Antidepressant-like effects in rats;a intra-BLA administration elicits anticonflict effects in rats subjected to the Vogel conflict testb | (See footnotes.) |
| ADX88178 | Reduced duration of immobility in the FST; attenuated conditioned freezing in the acquisition phase of the fear conditioning | Kalinichev et al., 2014 | ||
| Lu AF21934 | Anxiolytic, but not antidepressant-like, effects as measured by SIH, four-plate, marble-burying, and Vogel’s conflict tests | Sławińska et al., 2013b | ||
| mGlu7 | NAM | ADX71743 | Dose-dependent reduction in the number of buried marbles and increasing open arm exploration in EPM and marble-burying assays | Kalinichev et al., 2013 |
aKłak et al., 2007.
bStachowicz et al., 2004.
BLA, basolateral amygdala