TABLE 5

Interspecies differences in DMET abundance (pmol/mg protein)

TissueDMET ProteinsHumanMonkeyDogRatMouseReferences
LiverMDR1/Mdr1a0.40 ± 0.200.46 ± 0.100.59 ± 0.110.26 ± 0.03Wang et al., 2015
0.12 ± 0.010.02 ± 0.040.01 ± 0Hammer et al., 2021
MATE1/Mate10.48 ± 0.150.72 ± 0.15Wang et al., 2015
MRP2/Mrp21.54 ± 0.645.15 ± 1.531.93 ± 0.197.33 ± 1.16Yin et al., 2015
2.84 ± 0.44Hammer et al., 2021
MRP3/Mrp30.51 ± 0.150.76 ± 0.210.38 ± 0.05BLQWang et al., 2015
0.08 ± 0.010.13 ± 0.06Hammer et al., 2021
MRP4/Mrp4BLQBLQBLQBLQ
Wang et al., 2015
OCT1/Oct14.45 ± 1.8918.8 ± 6.80.50 ± 0.302.14 ± 0.47
BSEP/Bsep2.11 ± 0.504.45 ± 1.481.87 ± 0.372.31 ± 0.45
0.23 ± 0.011.02 ± 0.160.94 ± 0.26Hammer et al., 2021
NTCP/Ntcp2.17 ± 0.931.90 ± 0.247.91 ± 1.36Wang et al., 2015
0.21 ± 0.031.74 ± 0.2319.21 ± 3.52Hammer et al., 2021
Oatp1a20.70 ± 0.17
Wang et al., 2015
Oatp1b410.4 ± 2.3
OATP2B1/Oatp2b11.7 ± 0.60.30 ± 0.104.55 ± 2.00
OATP1B1/Oatp1b12.0 ± 0.912.7 ± 1.4
OATP1B3/Oatp1b31.1 ± 0.514.4 ± 2.1
Oatp1a13.91 ± 0.84
Oatp1a45.56 ± 1.40
Oatp1b26.43 ± 1.40
CYP1A1/Cyp1a10.09 ± 0.010.05 ± 0
Hammer et al., 2021
CYP1A2/Cyp1a25.93 ± 0.451.3 ± 0.49
CYP2B60.59 ± 0.04
CYP2C87.01 ± 0.55
CYP2C914.87 ± 0.67
CYP2C192.29 ± 0.07
CYP2D64.35 ± 0.25
CYP2E13.81 ± 0.2
CYP3A44.8 ± 0.2
CYP3A50.77 ± 0.04
Cyp2b100.21 ± 0
Cyp2c298.07 ± 0.93
Cyp2c380.03 ± 0
Cyp2c390 ± 0
Cyp2c550.01 ± 00.18 ± 0.03
Cyp2d918.4 ± 1.8
Cyp2d1016.7 ± 2.0
Cyp2e15.86 ± 0.9732.8 ± 2.2
Cyp3a250.24 ± 0.09
Cyp2b10.1 ± 0.03
Cyp2c1157.8 ± 15.7
Cyp2c120.43 ± 0.41
Cyp2c132.7 ± 2.7
Cyp2d311.1 ± 2.2
Cyp3a90.48 ± 0.15
Cyp3a181.0 ± 0.4
AO11.9617.87Basit et al., 2021
CES1569.06153.55
CES264.85491.69
SULT1A15.9723.01
SULT1B10.230.31
SULT1E11.071.60
SULT2A118.5917.63
SULT1A31.98
UGT1A10.870.29
UGT1A30.30.28
UGT1A61.025.70
UGT2B45.8332.25
UGT2B76.0120.73
UGT2B153.767.92
UGT2B170.21
KidneyMDR1/Mdr1a2.11 ± 0.681.86 ± 0.341.08 ± 0.351.13 ± 0.280.56 ± 0.21
Basit et al., 2019
MATE1/Mate15.21 ± 2.115.76 ± 1.75
MRP4/Mrp40.91 ± 0.622.58 ± 0.741.09 ± 0.210.32 ± 0.14
OAT1/Oat15.21 ± 1.828.51 ± 1.592.37 ± 0.948.96 ± 1.975.19 ± 3.25
OAT2/Oat20.97 ± 0.320.96 ± 0.3BLQ4.12 ± 1.37
OAT3/Oat33.84 ± 1.34.44 ± 1.03
OAT4/Oat40.51 ± 0.230.62 ± 0.2
OCT2/Oct28.16 ± 2.3416.72 ± 4.847.32 ± 1.7614.7 ± 4.88
OCTN1/Octn11.32 ± 0.510.63 ± 0.3
OCTN2/Octn20.64 ± 0.21.55 ± 0.330.53 ± 0.182.8 ± 0.591.48 ± 0.31
SGLT2/sglt23.68 ± 1.516.39 ± 1.3411.89 ± 2.8711.6 ± 2.2513.66 ± 2.91
AO1.533.10Basit et al., 2021
CES13.6544.14
CES235.172.48
SULT1A1BLQ2.97
SULT1B1BLQ0.15
SULT1E1BLQ1.05
SULT2A1BLQ0.40
SULT1A3BLQ
UGT1A1BLQ0.06
UGT1A3BLQ0.04
UGT1A60.220.41
UGT2B4BLQ0.23
UGT2B71.742.46
UGT2B15BLQ1.17
IntestineAOBLQ1.25Basit et al., 2021
CES13.562.37
CES2224.34388.08
SULT1A13.4415.18
SULT1B11.741.25
SULT1E11.085.29
SULT2A14.887.56
SULT1A36.8
UGT1A10.974.32
UGT1A30.034.58
UGT1A6BLQ0.88
UGT2B4BLQ0.12
UGT2B71.880.83
UGT2B152.23
UGT2B171.31