TABLE 3

Proteins against which CLR01 has been tested and the main related diseases

Protein/mutantInhibition of aggregationInhibition of toxicityAssociated disease
Aβ40, Aβ42Alzheimer’s disease
TauTauopathies
α-SynucleinSynucleinopathies
IAPPType 2 diabetes
CalcitoninMedullary Carcinoma of the thyroid
InsulinInjection-related amyloidosis
β2-MicroglobulinDialysis-related amyloidosis
TTRSenile systemic amyloidosis, familial amyloid polyneuropathy, familial amyloid cardiomyopathy
SOD1ALS
IgG light chainNA*Light-chain amyloidosis
TDP43NA*ALS, FTD
C9ORF72 RAN translation products containing ArgALS, others
SEVIHIV infection
P53Cancer
HuntingtinHuntington’s disease
PMSα1Bacterial biofilm
Ataxin 3Spinocerebellar ataxia type 3
αB-CrystallinDesmin-related cardiomyopathy
  • *NA – not available.