TABLE 1

Dissociation constants for MTs with Lys- or Arg-containing amino acids and peptides determined by fluorometric titration experimentsa

GuestKd (ยตM)
CLR01CLR02CLR04CLR05
Ac-Lys-OMe17b 9c68b28b 19c226b 643c
H-Lys-OH21b874b227c1170d
KAA30b905b303c33333d
KLVFF20b38c
KKLVFF4b71b
KKLVFFAK7b
KKKK10b
Ac-Arg-OMe60b 20c178b 77d882b 281d
H-Arg-OH699b,c609d
H-Arg-OMe160c
RGD86b
cRGDfV59c
cGRGDfL26d
IAPP1-79
IAPP2-14104
IAPP2-7No binding
  • aDutt et al. (2013a) and Lopes et al. (2015).

  • bPhosphate buffer 200 mM, pH=7.6.

  • cPhosphate buffer 10 mM, pH=7.6.

  • dPhosphate buffer 10 mM, pH=7.2.