TABLE 6

CYP450 inhibition

CYP450 IsoformStandard IC50 (μM)CLR01 IC50 (μM)
1A20.51 (naphthoflavone)>20
2D60.03 (quinidine)3.6
2C90.33 (sulphaphenazole)2.2
2C193.6 (troglitazone)1.5
3A40.03 (ketaconazole)1.7