TABLE 2

Subtypes of TNBC based on gene expression

SubtypesCharacteristics
Basal-like 1• Expression of cell cycle, proliferation, and DNA repair genes• High expression of ki-67 gene
Basal-like 2• Enriched in growth factor signaling pathway (epidermal growth factor receptor; the human gene, also known tyrosine-protein kinase Met; nerve growth factor and insulin-like growth factor-1 receptor)• Glycolysis and gluconeogenesis• Expression of myoepithelial
Immunomodulatory• Expression of gene involved in immune cell processes (cytotoxic T lymphocyte-associated molecule-4, IL7, interleukin 2, B cell, T cell, and natural killer cells)• Cytokine signaling
Mesenchymal• High expression gene of cell motility and extracellular matrix• Cell differentiation• Insulin-like growth factor
Mesenchymal stem-like• Similar to M with enrichment in genes involved in cell motility and extracellular matrix• Height expression of gene involved in stem cells pathway• Janus kinases signal transducers and activators of transcription activation
Luminal androgen receptor• Androgen receptor signaling• Height expression of gene involved in hormonally regulated signaling (steroid synthesis and metabolism)