Treatment vs. target half-life in the rat or mousea brain
| Target | Treatment | Inactivating agent | Species | Subregion | Recovery Half-life | Reference |
|---|---|---|---|---|---|---|
| Dopamine D1 receptor | Control (ECS) | EEDQ | Rat | Striatum | 3.3 d (80 h) | Nowak and Zak (1989) |
| Repeat ECS | EEDQ | Rat | Striatum | 2.3 d (55 h) | Nowak and Zak (1989) | |
| Vehicle | EEDQ | Rat | Striatum | 2.2 d (53 h) | Dewar et al. (1997) | |
| 6-OHDA | EEDQ | Rat | Striatum | 4.3 d (103 h) | Dewar et al. (1997) | |
| Chronic vehicle | EEDQ | Rat | Striatum | 6.0 d (144 h) | Zou et al (1996) | |
| Chronic (-)stepholidine | EEDQ | Rat | Striatum | 4.9 d (118 h) | Zou et al. (1996) | |
| Chronic vehicle (OVX) | EEDQ | Rat | Striatum | 2.3 d (55 h) | Levesque and Di Paolo (1991) | |
| Chronic estradiol (OVX) | EEDQ | Rat | Striatum | 4.4 d (107 h) | Levesque and Di Paolo (1991) | |
| Chronic vehicle (OVX) | EEDQ | Rat | Substantia nigra | 1.7 d (42 h) | Morissette et al. (1992) | |
| Chronic estradiol (OVX) | EEDQ | Rat | Substantia nigra | 1.4 d (34 h) | Morissette et al. (1992) | |
| Chronic vehicle (OVX) | EEDQ | Rat | Striatum (posterior) | 1.7 d (41 h) | Morissette et al. (1992) | |
| Chronic estradiol (OVX) | EEDQ | Rat | Striatum (posterior) | 3.8 d (91 h) | Morissette et al. (1992) | |
| Dopamine D2 receptor | Chronic vehicle | EEDQ | Rat | Striatum | 3.9 d (94 h) | Pich et al. (1987) |
| Chronic haloperidol | EEDQ | Rat | Striatum | 5.7 d (137 h) | Pich et al. (1987) | |
| Chronic vehicle | EEDQ | Rat | Striatum | 5.9 d (141 h) | Zou et al. (1996) | |
| Chronic (-)stepholidine | EEDQ | Rat | Striatum | 3.5 d (85 h) | Zou et al. (1996) | |
| Control (ECS) | EEDQ | Rat | Striatum | 1.2 d (29 h) | Nowak and Zak (1991a) | |
| Repeat ECS | EEDQ | Rat | Striatum | 2.4 d (58 h) | Nowak and Zak (1991a) | |
| Chronic vehicle | EEDQ | Rat | Striatum | 3.0 d (73 h)a | Leff et al. (1984) | |
| Chronic reserpine | EEDQ | Rat | Striatum | 5.4 d (130 h)a | Leff et al. (1984) | |
| Vehicle | EEDQ | Rat | Striatum | 4.8 d (116 h) | Neve et al. (1985) | |
| 6-OHDA | EEDQ | Rat | Striatum | 5.3 d (128 h) | Neve et al. (1985) | |
| Vehicle | EEDQ | Rat | Striatum | 3.8 d (90 h) | Dewar et al. (1997) | |
| 6-OHDA | EEDQ | Rat | Striatum | 4 d (96 h) | Dewar et al. (1997) | |
| Chronic vehicle (OVX) | EEDQ | Rat | Striatum (posterior) | 2.4 d (58 h) | Morissette et al. (1992) | |
| Chronic estradiol (OVX) | EEDQ | Rat | Striatum (posterior) | 4 d (95 h) | Morissette et al. (1992) | |
| Chronic vehicle (OVX) | EEDQ | Rat | Pituitary | 0.75 d (18 h) | Levesque and Di Paolo (1991) | |
| Chronic estradiol (OVX) | EEDQ | Rat | Pituitary | 2.1 d (51 h) | Levesque and Di Paolo (1991) | |
| Alpha1- adrenoceptor | Control (ECS) | EEDQ | Rat | Cortex | 1.6 d (39 h) | Nowak and Zak (1991b) |
| Repeat ECS | EEDQ | Rat | Cortex | 1.5 d (36 h) | Nowak and Zak (1991b) | |
| Alpha2- adrenoceptor | Chronic vehicle | EEDQ | Rat | Cortex | 3.9 d (94 h) | Barturen and Garcia-Sevilla, (1992) |
| Chronic desipramine | EEDQ | Rat | Cortex | 1.5-1.7 d (36-41 h) | Barturen and Garcia-Sevilla (1992) | |
| Chronic vehicle | EEDQ | Ratb | Cortex | 4.9 d (118 h) | Ribas et al., 1993) | |
| Chronic clorgyline | EEDQ | Ratb | Cortex | 3.6 d (86 h) | Ribas et al. (1993) | |
| Chronic vehicle | EEDQ | Ratc | Cortex | 8.1 d (194 h) | Ribas et al. (1993) | |
| Chronic clorgyline | EEDQ | Ratc | Cortex | 2.1 d (51 h) | Ribas et al. (1993) | |
| Chronic vehicle | EEDQ | Rat | Cortex | 6.4 d (154 h) | Ribas et al. (2001) | |
| Chronic reserpine | EEDQ | Rat | Cortex | 6.1 d (146 h) | Ribas et al. (2001) | |
| Chronic vehicle | EEDQ | Rat | Cortex | 8.2 d (197 h) | Carbonell et al. (2004) | |
| Chronic lithium | EEDQ | Rat | Cortex | 4.1 d (98 h) | Carbonell et al. (2004) | |
| Chronic vehicle | EEDQ | Rat | Cortex | 4.4 d (106 h) | Gabilondo and Garcia-Sevilla (1995) | |
| Chronic morphine | EEDQ | Rat | Cortex | 5.0 d (120 h) | Gabilondo and Garcia-Sevilla (1995) | |
| Morphine withdrawal | EEDQ | Rat | Cortex | 2.7 d (65 h) | Gabilondo and Garcia-Sevilla (1995) | |
| GABAA receptor | Chronic vehicle | EEDQ | Mouse | Cortex | 1.3 d (31 h) | Miller et al. (1991b) |
| /Bz sitea | Chronic lorazepam | EEDQ | Mouse | Cortex | 0.8 d (19 h) | Miller et al. (1991b) |
| Chronic vehicle | EEDQ | Mouse | Cerebellum | 1.8 d (42 h) | Miller et al. (1991b) | |
| Chronic lorazepam | EEDQ | Mouse | Cerebellum | 1.5 d (35 h) | Miller et al. (1991b) | |
| Dopamine transporter | Chronic vehicle | RTI-76 | Rat | Striatum | 2.1 d (50 h) | Kimmel et al. (2003) |
| (DAT) | Chronic cocaine | RTI-76 | Rat | Striatum | 0.94 d (23 h) | Kimmel et al. (2003) |
| Chronic vehicle | RTI-76 | Rat | Nucleus accumbens | 2.2 d (53 h) | Kimmel et al. (2003) | |
| Chronic cocaine | RTI-76 | Rat | Nucleus accumbens | 2.2 d (53 h) | Kimmel et al. (2003) |
ECS, electroconvulsive shock; OVX, ovariectomized; 6-OHDA, 6-hydroxydopamine.
aExtrapolated from data in Leff et al. (1984).
bSHR rats.
cWistar-Kyoto rats.