TABLE 2

BDE isolation markers and analyzed cargos for different neurodegenerative diseases

BDEMarkers Used for BDE Isolation for Cargo AnalysisCargo AnalysisReferences
ProteinmiRNA
Alzheimer's disease
NDEL1CAM (CD171), NCAM, ATP1A3, GAP43, NGLN 3Total tau, p-T181-tau, p-S396-tau, Aβ1–42, NRGN, REST, GAP43, cathepsin D, LAMP1, ubiquitin, synaptotagmin 1, pSer312-IRS-1, pY-IRS-1, Aβ1-42, SNAP-25, PSD-95, proBDNF, GluR2, Syntaxin-1, NPTX2, AMPA4, NLGN1, NRXN2α, SOD1, electron transport chain complexes, α-, β-, Δ-globin, hemoglobin, IL-6, MMP-9,miR-132, miR-212, miR-23a-3p, miR-223-3p, miR-190a-5p, miR-100-3p, miR-9-5p, miR-29a-5p, miR-106b-5p, miR-125b-5p, miR-132-5p, miR-135b-5p, miR-210-3p, miR-373, miR-204, Let-7eFiandaca et al., 2015; Goetzl et al., 2015a, b, 2016a, 2018a; Winston et al., 2016; Agliardi et al., 2019; Cha et al., 2019; Kapogiannis et al., 2019; Gu et al., 2020; Nogueras-Ortiz et al., 2020; Serpente et al., 2020; Arioz et al., 2021; Delgado-Peraza et al., 2021; Jia et al., 2021; Yao et al., 2021; Alvarez et al., 2022; Durur et al., 2022; Liu et al., 2022; Taşdelen et al., 2022; Eitan et al., 2023; Kumar et al., 2023; You et al., 2023
ADEGLAST (ACSA-1, EAAT-1), LRP-1BACE-1, γ-secretase, sAPPα, sAPPβ, Septin-8, p-T181-tau, P-S396-tau, Aβ42, GDNF, Integrin β1, LRP1, C1qmiR-29a-5p, miR-107, miR-125b-5p, miR-132-5p, miR-210-3pGoetzl et al., 2016b, 2018b; Nogueras-Ortiz et al., 2020; Delgado-Peraza et al., 2021; Liu et al., 2022; Kumar et al., 2023
MDECD11b, TMEM119FTH1, TREM2, taumiR-28-5p, miR-381-3p, miR-651-5p, and miR-188-5p, miR-29a-5p, miR-106b-5p, miR-125b-5p, miR-132-5p, miR-210-3pCohn et al., 2021; Kumar et al., 2023
ODEPDGFRαmiR-29a-5p, miR-107, miR-125b-5p, miR-135b-5p, miR-210-3pKumar et al., 2023
PDEPDGFRβmiR-9-5p, miR-125b-5p, miR-132-5p, miR-135b-5p, miR-210-3pKumar et al., 2023
EDECD31, CD146LAT-1, Glut-1, p-gp, Aβ40, Aβ42, PrPc, p-181T-taumiR-29a-5p, miR-125b-5p, miR-132-5p, miR-135b-5p, miR-210-3pAbner et al., 2020; Kumar et al., 202
Parkinson's disease
NDEL1CAM (CD171), NCAMα-Synuclein, tau aggregates, syntaxin-1A, VAMP-2, SNAP-25, DJ-1Shi et al., 2014; Si et al., 2019; Zhao et al., 2019; Jiang et al., 2020; Niu et al., 2020; Agliardi et al., 2021; Dutta et al., 2021; Kluge et al., 2022; Meloni et al., 2023;
ODEMOGα-SynucleinDutta et al., 2021
Schizophrenia
NDEL1CAMInsulin resistance markers (Akt and signaling effectors), Aβ42, Aβ40, P-T181-tauWijtenburg et al., 2019; Lee et al., 2021
ADEGLASTAβ42, Aβ40, P-T181-tauLee et al., 2021
Bipolar disorder
NDEL1CAMIRS-1, pS312-IRS-1, Akt, GSK-3β, p70S6K, ERK1/2, JNK, p70S6K, p38-MAPKMansur et al., 2021
Major depressive disorder
NDEL1CAM, SNAP-25IRS-1, mitochondrial proteins, IL-34, SynaptophysinmiR-423-3p, miR-191-5p, miR-486-5p, miR-30d-5p, miR-425-5p, miR-25-3p, miR-21-5p, miR-335-5p, and miR-126-5pKuwano et al., 2018; Goetzl et al., 2021; Nasca et al., 2021; Saeedi et al., 2021
ADEACSA-1Interferon-γ, IL-12p70, IL-1β, IL-2, IL-4, IL-6, TNF-α, and IL-17AXie et al., 2023b
Substance use disorders
NDEL1CAM,NFL, α-synuclein, Aβ1–42Let7a-5p, miR16–5p, miR-18–5p, miR107, miR-125–5p, miR-144–3p, miR-210–3p, miR-339–3p, and miR-361–5pKumar et al., 2021b
ADEGLASTNFL, α-synuclein, Aβ1–42Let7a-5p, miR16–5p, miR-18–5p, miR107, miR-125–5p, miR-144–3p, miR-210–3p, miR-339–3p, and miR-361–5pKumar et al., 2021b
MDETMEM119NFL, α-synuclein, Aβ1–42Let7a-5p, miR16–5p, miR-18–5p, miR107, miR-125–5p, miR-144–3p, miR-210–3p, miR-339–3p, and miR-361–5pKumar et al., 2021b
HIV-associated neurocognitive disorder
NDEL1CAMNFL, synaptophysin, HMGB1, NFL, Aβ, CD63, CD81, High mobility group box 1, p-T181-tau, cathepsin S, total tau, NCAM, contactin 5 and other 184 proteins by proximity extension assays.Sun et al., 2017, 2019a
  • ACSA-1, astrocyte cell surface antigen-1; AMPA4, glutamate ionotropic receptor 4; ATP1A3, ATPase Na+/K+ transporting subunit α 3; BACE-1, β secretase-1; C1q, complement component 1q; FTH1, ferritin heavy chain 1; GAP43, growth-associated protein 43; GDNF, glial-derived neurotrophic factor; GSK-3β, glycogen synthase kinase 3 β; HMGB1, high-mobility group box 1; LAMP1, lysosome-associated membrane protein 1; LRP1, lipoprotein receptor-related protein 1; MOG, myelin oligodendrocyte glycoprotein; NCAM, neural cell adhesion molecule; NLGN1, neuroligin 1; NLGN3, Neuroligin-3; NPTX2, neuron pentraxin 2; NRGN, neurogranin; NRXN2α, α-neurexin 2; p70S6K, p70 ribosomal S6 kinase; PDGFRα, platelet-derived growth factor α; PSD-95, postsynaptic density protein-45; REST, repressor element 1-silencing transcription factor; TREM2, triggering receptor expressed on myeloid cells 2; VAMP-2, vesicle-associated membrane protein-2.