Regular ArticleSuperoxide Scavenging by Mn(II/III) Tetrakis (1-Methyl-4-pyridyl) Porphyrin in Mammalian Cells
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2022, Biochimica et Biophysica Acta - General SubjectsAnalysis of binding ability of two tetramethylpyridylporphyrins to albumin and its complex with bilirubin
2016, Spectrochimica Acta - Part A: Molecular and Biomolecular SpectroscopyCitation Excerpt :In [22] Ghosh et al. described a way for PyP nanocomplexes constructed from single-stranded DNA assembles with meso-tetrakis-4-pyridylporphyrin which is capable for cell destruction via reactive oxygen species (ROS)-mediated mechanism. It is worth mentioned that PyPs may act both as photosensitizing agents [23] and ROS scavengers [24]. PyPs are widely applied in organic chemistry as building blocks [25,26].
ERK1/2 activation modulates pyocyanin-induced toxicity in A549 respiratory epithelial cells
2014, Chemico-Biological InteractionsCitation Excerpt :PCN is a redox-active pigment that is required for full virulence of P. aeruginosa in animal models and has been detected in the airway of secretions of patients with CF and bronchiectasis [25]. Oxidative stress has been demonstrated to be a central mechanism by which PCN produces cytotoxicity both in vitro and in vivo [1,9–11,15,26,27]. However, the cell signaling mechanisms responsible for cell death following PCN-induced oxidative stress remain poorly understood.
The SOD mimic MnTM-2-PyP(5+) reduces hyaluronandegradation-induced inflammation in mouse articularchondrocytes stimulated with Fe (II) plus ascorbate
2013, International Journal of Biochemistry and Cell BiologyCitation Excerpt :Manganese ion has been shown to scavenge both superoxide and H2O2 and to inhibit iron-induced lipid peroxidation (Sziraki et al., 1999; Gray and Carmichael, 1992). The proposed mechanism by which MnTMPyP5+ scavenges superoxide in mammalian cells involves the reduction of Mn(III)TMPyP5+ to Mn(II)TMPyP5+ by cellular reductants and a subsequent reductive scavenging of superoxide (Gardner et al., 1996). Metalloporphyrins are stable redox-active compounds that can catalytically consume H2O2 and protect endothelial cells from the damaging effects of H2O2.
Ascorbic acid: Chemistry, biology and the treatment of cancer
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