Regular ArticleBiological Activities of Two Porcine Growth Hormone-Releasing Hormone Receptor Isoforms
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Key pituitary miRNAs mediate the expression of pig GHRHR splice variants by regulating splice factors
2022, International Journal of Biological MacromoleculesCitation Excerpt :It is well documented that hypothalamic growth hormone releasing hormone (GHRH) stimulates the synthesis and secretion of pituitary growth hormone (GH) [1,2], then further regulates the organism growth, metabolism and biosynthesis, all of these biological functions are mediated by GHRH receptor (GHRHR) [3–6]. In mammals, GHRHR splice variants (SVs) with altered signaling properties and ligand-binding affinity have been reported [7,8] and it has become increasingly clear that mRNA alternative splicing of GHRHR gene may generate multiple functional GHRHR variants and represent an additional level to control the actions of GHRH under different physiological conditions [9,10]. However, the current research has mostly focused on the presence of GHRHR SVs and their potential roles in the pituitary [7,11,12], the factors involved in the formation of GHRHR SVs and their molecular mechanisms have rarely been reported.
Molecular characterization of the GHRH/GHRH-R and its effect on GH synthesis and release in orange-spotted grouper (Epinephelus coioides)
2012, Comparative Biochemistry and Physiology - B Biochemistry and Molecular BiologyCitation Excerpt :These residues may form a disulfide bond, and thus could contribute to the stability and tertiary structure of the receptor (Harmar, 2001; McKibbin et al., 2007). In several species, including human, mouse, pig and chicken, alternatively spliced GHRH receptor transcripts had been found (Hashimoto et al., 1995; Hassan;, 2001; McElvaine and Mayo, 2006; Wang et al., 2007a). However, we did not identify any alternatively spliced GHRH-R transcripts from the orange-spotted grouper.
Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system
2006, Fertility and SterilityGrowth Hormone-Releasing Hormone
2006, Handbook of Biologically Active Peptides
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