Biochemical and Biophysical Research Communications
Regular ArticleIsolation of a Human κ Opioid Receptor cDNA from Placenta
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Bifunctional opioid receptor ligands as novel analgesics
2019, NeuropharmacologyCitation Excerpt :In contrast to μ- and δOP receptors, κOP receptors are largely expressed on presynaptic dopaminergic membranes and inhibit presynaptic neurotransmitter release on activation. Three κOP receptor variants have been characterized (κ1-3OP receptors), though only one (κ1OP receptor) has been cloned (Rothman et al., 1989; Mansson et al., 1994). The κOP receptors are broadly expressed throughout the CNS, including the mesolimbic system, hypothalamus, amygdala, spinal cord, and hypothalamic-pituitary axis (Mansour et al., 1995; Peng et al., 2012; Butelman and Kreek, 2015).
GPCR homology model template selection benchmarking: Global versus local similarity measures
2019, Journal of Molecular Graphics and ModellingBioinformatics and Evolution of Vertebrate Nociceptin and Opioid Receptors
2015, Vitamins and HormonesCitation Excerpt :The ultimate discovery and isolation of the cDNA for the mouse delta-opioid receptor (mDOR1) from the labs of Evans in the United States and Kieffer in France in 1992 (Evans, Keith, Morrison, Magendzo, & Edwards, 1992; Kieffer, Befort, Gaveriaux-Ruff, & Hirth, 1992) for the first time linked an opioid receptor sequence to a pharmacologically defined opioid receptor. Once the mDOR cDNA sequence was known, homology cloning led to the identification of receptor sequences for numerous rodent, monkey, and the human opioid receptors, hMOR (Wang, Johnson, Persico, et al., 1994), hDOR (Knapp et al., 1994; Simonin et al., 1994), and hKOR (Mansson, Bare, & Yang, 1994; Simonin et al., 1995; Zhu et al., 1995). At the same time, cloning studies revealed another “opioid receptor-like” (ORL) sequence from numerous labs that was similar to an opioid receptor but did not look like one from pharmacological studies (Bunzow et al., 1994; Chen et al., 1994; Fukuda et al., 1994; Lachowicz, Shen, Monsma, & Sibley, 1995; Mollereau et al., 1994; Wang, Johnson, Imai, et al., 1994; Wick et al., 1994).
Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies
2011, Bioorganic and Medicinal ChemistryCitation Excerpt :Three types of opioid receptors (μ, δ, κ) are now well established not only by pharmacological studies but also by molecular biological characterizations.1–4