Biochemical and Biophysical Research Communications
Regular ArticleQuantification of α1-Adrenoceptor Subtypes in Human Tissues by Competitive RT-PCR Analysis
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Modulation of Immune Cell Function by α1-Adrenergic Receptor Activation
2011, Current Topics in MembranesCitation Excerpt :Murine bone marrow expresses α1A- and α1B-AR mRNA while human bone marrow transcriptionally expresses the α1B- and α1D-AR subtypes (Maestroni et al., 1992; Kavelaars, 2002). High levels of α1A- and α1B-AR mRNA are present in the human spleen (Price et al., 1993; Faure et al., 1995), while others have reported the expression for all three α1-AR subtypes (Kavelaars, 2002). The majority of studies examining immune cell α1-AR expression have been performed on peripheral blood mononuclear cell (PMBC) preparations, which include several blood cell types including T cells, B cells, NK cells, monocytes, and macrophages.
Alpha-1A adrenoceptor
2007, xPharm: The Comprehensive Pharmacology ReferenceAlpha-1b adrenoceptor
2007, xPharm: The Comprehensive Pharmacology ReferenceAlpha-1D adrenoceptor
2007, xPharm: The Comprehensive Pharmacology ReferenceAdaptive immunity in mice lacking the β<inf>2</inf>-adrenergic receptor
2003, Brain, Behavior, and ImmunityRegulated expression of α-1 adrenergic receptors in the immune system
2002, Brain, Behavior, and ImmunityCitation Excerpt :We have investigated the expression of α1-AR by RT-PCR in mononuclear cells isolated from human primary and secondary lymphoid organs (Table 1). In line with earlier reports, we observed a low expression of α1d-AR mRNA and a higher expression of α1a-and α1b-AR mRNA in human spleen (Faure et al., 1995; Price et al., 1994). In contrast, using this sensitive technique, we did not detect any α1-AR mRNA in peripheral blood mononuclear cells (PBMC) from 18 out of 20healthy individuals.