Biochemical and Biophysical Research Communications
Regular ArticleNo Association between Parkinson's Disease and Low-Activity Alleles of CatecholO-Methyltransferase
References (0)
Cited by (86)
Catechol-O-methyltransferase Val158Met polymorphism influences prefrontal executive function in early Parkinson's disease
2016, Journal of the Neurological SciencesCitation Excerpt :The met/met patients were on a higher dose of levodopa compared to the val/val and val/met patients (Table 2). In the present study, we failed to find a significant difference of COMT Val158Met allele frequency and genotype distributions between PD patients and controls in a Chinese Han population, in accordance with other studies in the Caucasian population [30–33]. However, a meta-analysis found that the COMT polymorphisms may be associated with PD in Asians rather than Caucasians [34].
Modulating effect of COMT Val<sup>158</sup>Met polymorphism on interference resolution during a working memory task
2015, Brain and CognitionCitation Excerpt :Because our main objective was to explore genotype-related effects on the brain substrates for interference resolution and cognitive control, our participants were selected from a larger sample in order to create three COMT-genotype groups (VV, VM and MM) of 15 participants each matched for age, sex and fluid intelligence. However, in Caucasians, VM individuals represent 50% of the general population whereas people homozygous for the Val and Met allele represent approximately 25% each (Hoda et al., 1996; Palmatier, Kang, & Kidd, 1999). The results we obtained here are mainly driven by the VV homozygous individuals.
Association analysis of serotonin and catecholamine system candidate genes in obsessive-compulsive disorder in the Chinese population
2011, Psychiatry ResearchCitation Excerpt :The polymorphisms investigated were 5-HT2A-1438G/A, HTR1B-G861C, DRD2-141CIns/Del, DRD3-Ser9Gly, DRD4-521C/T and COMT-Val158Met. Target genomic fragments, containing these polymorphisms, were amplified by means of polymerase chain reaction (PCR) and genotyped using published primer sequences and protocols (5-HT2A, Sato et al., 2002; HTR1B, Nöthen et al., 1994; DRD2, Arinami et al., 1997; DRD3, Shaikh et al., 1996; DRD4, Ronai et al., 2001; COMT, Hoda et al., 1996). The Statistical Package for the SAS 9.14 computer program was used for statistical analysis of the data.
Genetic, personality, and environmental predictors of drug use in adolescents
2010, Journal of Substance Abuse TreatmentCitation Excerpt :The presence of the 9R homozygote (9R/9R) or heterozygote (9R/N9R) was considered a genetic risk marker for hypodopaminergic functioning compared to the absence of the 9R (N9R/N9R). COMT polymorphism was determined by a standard PCR procedure (Hoda et al., 1996). The resultant PCR product was digested by N1aIII restriction endonuclease, and the DNA fragments resolved by 4% agarose gel electrophoresis.
- 1
To whom correspondence should be addressed. E-mail: [email protected]; Fax: 0171 701 9044. [email protected]; Fax: 0121 627 2061.