Biochemical and Biophysical Research Communications
Regular ArticleSerum Amyloid A Is a Chemotactic Agonist at FPR2, a Low-Affinity N-Formylpeptide Receptor on Mouse Neutrophils
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2021, JACC: Basic to Translational ScienceCitation Excerpt :In the HL-60 FPR2 KO line, no enhancement in chemotaxis with BMS-986235 was obtained. When HL-60 cells were pretreated with BMS-986235, chemotaxis toward serum amyloid A (SAA), a potent proinflammatory apolipoprotein and a known ligand for FPR2 (16), was inhibited with a half maximal inhibitory concentration value of 21 nM. A similar antagonist profile was obtained with FPR1-deficient HL-60 cells (half maximal inhibitory concentration = 14 nM).
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2018, American Journal of PathologyCitation Excerpt :Previous studies have demonstrated that SAA1 promotes chemotaxis in neutrophils through FPR2, rather than FPR1, signaling. Therefore, the FPR2-specific receptor antagonist WRW43,17,18 and the FPR1 receptor antagonist cyclosporine H15 were used. Cells treated with WRW4 demonstrated markedly reduced wound closure compared with control cells (Figure 3, A and B).
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