Biochemical and Biophysical Research Communications
Regular ArticleGenomic Structure and in Vivo Expression of the Human Organic Anion Transporter 1 (hOAT1) Gene☆
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2018, Comprehensive Toxicology: Third EditionDrug transport by Organic Anion Transporters (OATs)
2012, Pharmacology and TherapeuticsCitation Excerpt :Oat1 sequences derived from many more species are deposited in gene banks, but functional studies were not reported. Four splice variants of human OAT1 occur in kidneys, the longer two of them (OAT1-1; OAT1-2) having identical transport functions and the shorter two (OAT1-3; OAT1-4) lacking transport capability (Bahn et al., 2000, 2004). Human OAT1-2 is composed of 546 amino acids.
Uptake Transporters
2010, Comprehensive Toxicology, Second EditionMechanisms of renal anionic drug transport
2008, European Journal of PharmacologyCitation Excerpt :Similarly, human OAT3 is expressed in the kidney and, to a lesser extent, in the brain (Cha et al., 2001) and the BLM of choroid plexus (Alebouyeh et al., 2003). Four human OAT1 splice variants have been identified, designated OAT1-1 till 4, which consist of 563, 550, 506, and 529 amino acids, respectively (Bahn et al., 2000). OAT1-2 lacks 13 amino acids within its intracellular COOH-terminus and is considered the main human orthologue of OAT1.
Organic Anion and Cation Transporters in Renal Elimination of Drugs
2008, Seldin and Giebisch's The KidneyOrganic Anion and Cation Transporters in Renal Elimination of Drugs
2007, Seldin and Giebisch's The Kidney: Physiology & Pathophysiology 1-2
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The nucleotide sequences reported in this paper have been submitted to EMBL/GenBank with Accession Nos. AJ249369 (OAT1 gene), AJ251529 (isoform hOAT1-3), and AJ271205 (isoform hOAT1-4).
- 1
These authors contributed equally to this study.
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