Biochemical and Biophysical Research Communications
Regular ArticleExpression of the Melanocortin 5 Receptor on Rat Lymphocytes
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TFOS DEWS II Sex, Gender, and Hormones Report
2017, Ocular SurfaceCitation Excerpt :The melanocortins α-MSH and ACTH are involved in the control of constitutive proteins by the lacrimal gland. These hormones have receptors on acinar epithelial cells of the rat lacrimal gland [738,740,774–777] and may stimulate cAMP production and protein release [737,738,740,778,779]. However, α-MSH and ACTH do not influence the output of all (e.g. regulated) lacrimal gland proteins [366].
Role of the hypothalamo-pituitary-adrenal axis in the modulation of pollinosis induced by pollen antigens
2010, Allergology InternationalRegulatory Pathways in Lacrimal Gland Epithelium
2003, International Review of CytologyCitation Excerpt :They stimulate secretion by increasing cellular cAMP levels. Of the five cloned melanocortin receptors, only the melanocortin 5 recptor (MC5-R) is present on lacrimal gland cells (van der Kraan et al., 1998; Akbulut et al., 2001). This receptor has high affinity binding for both α-MSH and ACTH1–24 and could mediate the effects of both hormones on lacrimal gland secretion.
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