Regular Article2-Chloroadenosine Inhibits the MHC-Unrestricted Cytolytic Activity of Anti-CD3-Activated Killer Cells: Evidence for the Involvement of a Non-A1/A2 Cell-Surface Adenosine Receptor
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Adenosine receptors and cancer
2011, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :It has been demonstrated that colon adenocarcinoma cells inhibited anti-CD3-activated killer cell induction through the production of a tumor-associated soluble factor that was distinct from transforming growth factor-beta (TGF-β) or prostaglandins [14]. Therefore, adenosine was indicated as a possible inhibitor of killer T-cell activation in the microenvironment of solid tumors [15,16]. Indeed, evaluating the adhesion of murine spleen-derived anti-CD3-activated killer (AK) lymphocytes to syngeneic MCA-38 colon adenocarcinoma cells, it was found that adenosine reduced adhesion by up to 60% [17].
The A<inf>3</inf> adenosine receptor: An enigmatic player in cell biology
2008, Pharmacology and TherapeuticsAdenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
2006, Pharmacology and TherapeuticsAdenosine stimulation of the proliferation of colorectal carcinoma cell lines: Roles of cell density and adenosine metabolism
2003, Biochemical PharmacologyCitation Excerpt :Under hypoxic conditions, as in tumors in vivo, the generation rate of adenosine through AMP nucleotidase would be much higher, shifting the major role in intracellular breakdown over to ADA, which has a much higher Km (70 μM) but far greater capacity for adenosine metabolism than AK [56]. We have previously shown that adenosine can dramatically suppress the anti-tumor immune response [12–17]. Adenosine may also act to promote tumor cell migration [57] and stimulate angiogenesis [58,59], as well as increase intratumoral blood flow [60], and confer protection against radiotherapy [61].
Adenosine suppresses α<inf>4</inf>β<inf>7</inf> integrin-mediated adhesion of T lymphocytes to colon adenocarcinoma cells
2002, Experimental Cell Research2 The Adenosine A<inf>3</inf> Receptor and its Ligands
2001, Progress in Medicinal Chemistry