Regular ArticleHuman Topoisomerase IIα and IIβ Interact with the C-Terminal Region of p53
References (56)
- et al.
Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme
J. Biol. Chem.
(1987) - et al.
Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells
FEBS Lett.
(1990) - et al.
Novel HeLa topoisomerase II is the IIβ isoform: Complete coding sequence and homology with other type II topoisomerases
Biochim. Biophys. Acta
(1993) - et al.
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
Cell
(1993) p53, the cellular gatekeeper for growth and division
Cell
(1997)- et al.
p53 and its 14 kDa C-terminal domain recognise primary DNA-damage in the form of insertion-deletion mismatches
Cell
(1995) - et al.
Small peptides activate the latent sequence-specific DNA binding function of p53
Cell
(1995) - et al.
WAF1, a potential mediator of p53 tumor suppression
Cell
(1993) - et al.
Binding of wild-type p53 by topoisomerase II and overexpression of topoisomerase II in human hepatocellular carcinoma
Biochem. Biophys. Res. Commun.
(1997) - et al.
Nuclear distribution of DNA topoisomerase IIβ: A potent nuclear targeting signal resides in the C-terminal 116 amino acids
Exp. Cell Res.
(1998)
Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase IIβ
J. Biol. Chem.
Bipartite nuclear localization signals in the C terminus of human topoisomerase IIα
Exp. Cell Res.
DNA topoisomerases
Annu. Rev. Biochem.
Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II
Biochemistry (USA)
Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isoenzymes
Proc. Natl. Acad. Sci. USA
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21–22
Proc. Natl. Acad. Sci. USA
Human cells express two differentially spliced forms of topoisomerase IIβ mRNA
Nucleic Acids Res.
Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24
Nucleic Acids Res.
Etoposide targets topoisomerase IIα and IIβ in leukemic cells: Isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique
Mol. Pharmacol.
p53 status and the efficacy of cancer therapy in vivo
Science
p53: Puzzle and paradigm
Genes Dev.
Proteolytic cleavage of p53: A model for the activation of p53 in response to DNA damage
Oncol. Res.
Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G(1) arrest
Proc. Natl. Acad. Sci. USA
Alternatively spliced forms in the carboxy-terminal domain of p53 protein regulate its ability to promote annealing of complementary single strands of nucleic-acids
Mol. Cell. Biol.
Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21
Oncogene
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
Genes Dev.
Cited by (55)
Multiomics Reveals Ectopic ATP Synthase Blockade Induces Cancer Cell Death via a lncRNA-mediated Phospho-signaling Network
2020, Molecular and Cellular ProteomicsPolymer grafted magnetic nanoparticles for delivery of anticancer drug at lower pH and elevated temperature
2016, Journal of Colloid and Interface ScienceMolecular cytogenetic evaluation of the efficacy of photodynamic therapy by indocyanine green in breast adenocarcinoma MCF-7 cells
2013, Photodiagnosis and Photodynamic TherapyCitation Excerpt :In addition, the chromosomal machinery through which the oncogene amplification is generated is largely unknown [40–42]. TOP2A gene is important to complete processes of cell division and any defect on this gene will lead to chromosomes accumulation and will stimulate cell death via apoptosis [43]. ICG/PDT induced DNA damage due to the induction of 1O2 from ICG after exposure to laser irradiation [25,26], the generation of 1O2 evoked rapid multiple consequences that trigger apoptosis after laser exposure.
Effect of p53 genotype on gene expression profiles in murine liver
2008, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisTranslocations of 17q21∼qter in neuroblastoma cell lines infrequently include the topoisomerase IIα gene
2006, Cancer Genetics and Cytogenetics
- 1
Current address: Division of Integrative Biology, The Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS.
- 2
To whom correspondence and reprint requests should be addressed at School of Biochemistry and Genetics, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH. Fax: 0191 222 7424. E-mail: [email protected].