Regular ArticleChromosomal Localization and cDNA Cloning of the Human DBP and TEF Genes
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Report of interstitial 22q13.1q13.2 microduplication in two siblings with distinctive dysmorphic features, heart defect and mental retardation
2013, European Journal of Medical GeneticsCitation Excerpt :The causative role of NPTRX gene has already been suggested by Shimojima et al. The duplicated area also contains synaptogyrin, L3MBTL2, TEF, PMM1 and POLDIP3 genes that are known to be highly expressed in the brain and could contribute to the development of mental retardation [20–24]. Shimojima et al. [9], however, reported a boy with a short stature and mild mental retardation carrying a de novo 6 Mb interstitial duplication at 22q13.1q13.31, but without evident abnormal behavioural phenotype or hippocampal malformation on MRI.
A novel role for proline- and acid-rich basic region leucine zipper (PAR bZIP) proteins in the transcriptional regulation of a BH3-only proapoptotic gene
2006, Journal of Biological ChemistryCitation Excerpt :More recently, TEF has been associated with down-regulation of the common β chain of cytokine receptors, but no transcriptional mechanism was defined (30). Although this transcription factor is expressed in the pituitary gland during embryonic development, it appears in several tissues in the mature organism, including brain, lung, liver, spleen, and kidney (7). We have determined the expression of TEF mRNA in NTERA2, 2102Ep, HCT116, and RT112 cells.
TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common β chain of cytokine receptors
2005, BloodCitation Excerpt :Nondenaturing polyacrylamide gels containing 4% acrylamide and 2.5% glycerol were prerun at 4°C in a high–ionic-strength Tris-glycine buffer for 30 minutes, loaded with the samples containing protein–DNA complexes, run at 35 mA for approximately 90 minutes, dried under vacuum, and analyzed by autoradiography. The 3 members of the PAR family of proteins are differentially expressed in tissues and organs.8,10,40 In contrast to HLF, which shows tissue-specific expression, TEF and DBP are expressed ubiquitously, although their expression in normal hematopoietic and lymphoid tissues has not been clarified.
A PAR domain transcription factor is involved in the expression from a hematopoietic-specific promoter for the human LMO2 gene
2003, BloodCitation Excerpt :TEF was originally described in the developing anterior pituitary gland29 and was demonstrated to bind to an element in the thyroid-stimulating hormone-β promoter and activate transcription of this gene.29 Subsequent studies have shown the TEF gene to be widely expressed in adult tissues including liver, brain, kidney, spleen, testes, and lung.30,31 HLF is predominantly expressed in liver and kidney with lower levels in the lung and brain.32
The DBP transcriptional activation domain is highly homologous to that of HLF and TEF and is not responsible for the tissue type-specific transcriptional activity of DBP
2001, GeneCitation Excerpt :We also present evidence that further delineates a minimal 13 amino acid region of the HLF THAD that contains all of its transcriptional activity. A complete human DBP cDNA clone was a kind gift of Tom Look (Khatib et al., 1994). A nine amino acid FLAG epitope (amino acid sequence DYKDDDDK) was fused in-frame to the carboxyl terminus of DBP via PCR and the product was cloned into pRc/RSV (Invitrogen; Carlsbad, CA) to create pRc/RSV-DBP-FLAG.