Regular ArticleCelsr1, a Neural-Specific Gene Encoding an Unusual Seven-Pass Transmembrane Receptor, Maps to Mouse Chromosome 15 and Human Chromosome 22qter☆
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Cited by (59)
Regulation of cell polarity by cell adhesion receptors
2018, Seminars in Cell and Developmental BiologyCitation Excerpt :The members of the Fmi/Celsr (i.e. Cadherin epidermal growth factor laminin G seven-pass transmembrane GPCR type receptors) 7TM domain cadherins subfamily are conserved in animals across phyla ranging from ascidians and worms over flies to vertebrates. The founding member of this superfamily, Flamingo/Starry night, was identified in Drosophila and since then its homologs (Celsr1-3) were also described in mice, zebrafish, Xenopus [77,90–93]. In contrast to vertebrates, Caenorhabditis elegans has only one gene, fmi-1 [94].
Neuronal territory formation by the atypical cadherins and clustered protocadherins
2017, Seminars in Cell and Developmental BiologyCitation Excerpt :Flamingo and the mammalian homologs Celsr1-3 are atypical cadherins with a seven-pass transmembrane domain similar to G protein–coupled receptors, a feature unique to this subfamily (Fig. 1). They are large proteins composed of nine extracellular cadherin repeats, three cysteine-rich motifs, several EGF-like repeats, and two laminin globular domains [5,6]. Analysis of the Drosophila Fmi mutant and the Celsr1 mouse mutant revealed central roles in planar cell polarity (PCP) and in neuronal patterning [6,7].
Atypical cadherins Celsr1-3 and planar cell polarity in vertebrates
2013, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Celsr genes were first identified in the mouse.1–3
Celsr1-3 Cadherins in PCP and Brain Development
2012, Current Topics in Developmental BiologyIdentification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study
2009, AtherosclerosisCitation Excerpt :They also contain seven transmembrane domains, a characteristic specific to this subfamily. These proteins are thought to function as receptors in contact-mediated communication, with the cadherin domains acting as homophilic binding regions and the EGF-like domains contributing to cell adhesion and receptor–ligand interactions (Entrez Gene, NCBI) [15–17]. In situ hybridization and reverse transcription-polymerase chain reaction analysis have revealed substantial levels of Celsr1 expression in the neural tube, brain, lung epithelium, and nascent eyelid of mouse embryos at embryonic day 11.5.
Adhesion-GPCRs: emerging roles for novel receptors
2008, Trends in Biochemical Sciences
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C. D. SternP. W. H. Holland, Eds.
- 1
Present address: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada.
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To whom correspondence should be addressed. Telephone: 44-171 594 5288. Fax: 44-171 823 7525. E-mail: [email protected].