Regular ArticleThe Neuronal Norepinephrine Transporter in Experimental Heart Failure: Evidence for a Posttranscriptional Downregulation☆,☆☆
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2022, Nuclear Medicine and Molecular Imaging: Volume 1-4Monoamine oxidases in age-associated diseases: New perspectives for old enzymes
2021, Ageing Research ReviewsCitation Excerpt :This SNS hyperactivity affects the heart, the skeletal muscles and the gut. An increase in SNS activity is also reported in obese and diabetic subjects (Balasubramanian et al., 2019; Straznicky et al., 2012), and in chronic heart failure (HF) where combined NE spillover and reduced neuronal uptake by norepinephrine transporter (NET) occur (Backs et al., 2001; Eisenhofer et al., 1996). In this latter case, uptake of NE is favored in cardiomyocytes and stimulates MAO-A enzymatic activity (Kaludercic et al., 2014b).
Nuclear Imaging of the Cardiac Sympathetic Nervous System: A Disease-Specific Interpretation in Heart Failure
2020, JACC: Cardiovascular ImagingCitation Excerpt :Because most of the histological evidence in humans is limited to patients undergoing heart transplant, this body of evidence is limited to patients with end-stage disease, and may not reflect the neuronal state of patients with stable or early disease and/or milder impairments in ventricular function. Backs et al. (43) used an aortic banding model of chronic HF and showed a 37% reduction in NE uptake within the LV, and an associated 41% reduction of uptake-1 expression. The density of sympathetic nerve fibers within the heart was unchanged.
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Presented in part at the 72nd Scientific Sessions of the American Heart Association in November 1999 in Atlanta/Georgia.
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Please address all correspondence to: Markus Haass, MD, Department of Cardiology, University of Heidelberg, Bergheimer Str. 58, D-69115 Heidelberg, Germany. E-mail: [email protected]