Regular ArticleHomer-1c/Vesl-1L Modulates the Cell Surface Targeting of Metabotropic Glutamate Receptor Type 1α: Evidence for an Anchoring Function
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Sex differences and hormonal regulation of metabotropic glutamate receptor synaptic plasticity
2023, International Review of NeurobiologyCitation Excerpt :Long form splice variants of Group 1 Homer proteins (Homer1b and Homer1c) differentially regulate mGlu1/5 receptor trafficking on the post-synaptic membrane. In cultures from male rodents, Homer1b inhibits mGlu5 receptor trafficking to the cell surface (Roche et al., 1999), whereas co-expression of Homer1c increases surface expression of mGlu1 receptors (Ciruela et al., 2000; Xiao, Gustafsson, & Niu, 2006). To our knowledge, these findings have not been replicated in cultures from female animals.
The Homer1 family of proteins at the crossroad of dopamine-glutamate signaling: An emerging molecular “Lego” in the pathophysiology of psychiatric disorders. A systematic review and translational insight
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Homer family consists of several proteins encoded by Homer 1, 2, 3 genes, providing both constitutive (Homer1b/c, Homer2a/b, Homer3) and inducible (Homer1a and Ania-3) isoforms (Fig. 1) (de Bartolomeis and Iasevoli, 2003; Shiraishi-Yamaguchi and Furuichi, 2007). Homer1 long isoforms are constitutively expressed in neurons (Soloviev et al., 2000) and display two major domains: i) the N-terminal enabled/vasodilator-stimulated phosphoprotein homology (EVH1) domain, through which physically bridge multiple PSD targets (Table 1), such as group 1 metabotropic glutamate receptor (mGluR) and inositol 1,4,5-trisphosphate receptor (IP3R) (Tu et al., 1998); ii) the C-terminal coiled-coil (CC) structure followed by a leucine-rich stretch which allows for self-multimerization (Ciruela et al., 2000; Szumlinski et al., 2006; Xiao et al., 1998, 2000). Moreover, Homer multimeric clusters interact with Shank, and Homer-Shank complex may link the N-methyl-D-aspartate glutamate receptor (NMDAR)-postsynaptic density protein of 95 kDa (PSD-95) complex (Tu et al., 1999), through the scaffolding molecule guanylate kinase-associated protein (GKAP) (Shin et al., 2012; Tong et al., 2014a, 2014b) (Table 1).
Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments
2021, NeuronCitation Excerpt :Future work will be required to determine how transcriptional or translational changes potentially alter mGluR1 expression on ChIs. Degradation or posttranslational modification may also contribute to the decreased functional expression following loss of dopamine, as altered expression of scaffolding molecules such as Homer1, which regulates mGluR surface trafficking (Brakeman et al., 1997; Ciruela et al., 2000; Roche et al., 1999), is decreased following dopamine depletion (Kurz et al., 2010; Kuwajima et al., 2007). In Parkinson’s patients, dopaminergic denervation initially emerges in the putamen (DLS).