Regular ArticleHypoxia-Induced Hyperpermeability in Brain Microvessel Endothelial Cells Involves VEGF-Mediated Changes in the Expression of Zonula Occludens-1
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2021, Trends in NeurosciencesCitation Excerpt :Hypoxia induces expression of hypoxia-inducible factor-1; a major transcriptional regulator of the Vegf gene [85]. VEGF is expressed mainly by activated astrocytes upon hypoxic stress [86] and it has been reported to induce changes in TJ proteins such as ZO-1 [87], claudin-5, and occludin [88,89]. VEGF also induces increased vascular permeability via release of NO through endothelial NO synthase (NOS) activation [90].
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