Regular ArticleMDMA (‘ecstasy’) exhibits an anxiogenic-like activity in social encounters between male mice
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Cited by (44)
Of mice and men on MDMA: A translational comparison of the neuropsychobiological effects of 3,4-methylenedioxymethamphetamine (‘Ecstasy’)
2020, Brain ResearchCitation Excerpt :Oxytocin, 5-HT1A and GABAB receptors, as well as several proteins from the cerebral cortex, hippocampus and amygdala involved in energy maintenance, seem to be involved in MDMA-induced sociability (Kuteykin-Teplyakov and Maldonado, 2014). In addition, acute MDMA (1–20 mg/kg) dose-dependently reduces aggressive behaviour (Maldonado and Navarro, 2001; Miczek and Haney, 1994; Navarro and Maldonado, 1999). However, this effect does not seem to be associated with the increase in pro-social behaviour and, conversely, may result from increased social anxiety.
Effects of para-methoxyamphetamine (PMA) on agonistic encounters between male mice
2018, Pharmacology Biochemistry and BehaviorCitation Excerpt :However, these treatments affect global serotoninergic neurotransmission, and may trigger several undesired side effects given the multiplicity of behaviors and physiological processes modulated by this neurotransmitter (for a review see Hale et al., 2012). In contrast to PMA, the effects of MDMA on agonistic behaviors have been widely studied, and an antiaggressive effect of MDMA has been reported in the resident-intruder test (Miczek and Haney, 1994), isolation induced aggression model (Maldonado and Navarro, 2001; Navarro and Maldonado, 1999, 2004) and in social interaction models (Machalova et al., 2012; Morley and McGregor, 2000). However, this antiaggressive effect shown by MDMA seems to be nonspecific, since it is accompanied by other behaviors that suggest an anxiogenic effect of the drug (Machalova et al., 2012; Maldonado and Navarro, 2001; Navarro and Maldonado, 1999).
The prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA): Controlled studies in humans and laboratory animals
2015, Neuroscience and Biobehavioral ReviewsCitation Excerpt :However, while these doses reduced aggressive behavior they also potentiated social anxiety-like behavior (avoidance, defense, and submission postures) and reduced social investigation compared to placebo. Analogous findings were reported in a more recent study involving similar doses (8 and 15 mg/kg; Maldonado and Navarro, 2001). Additionally, MDMA (15 mg/kg) reduced overall aggression but also decreased social exploration compared to placebo in adult male Agouti rats (Kirilly et al., 2006).
Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice
2012, Pharmacology Biochemistry and BehaviorCitation Excerpt :The possible dual action of MDMA was shown in mice tested in an elevated plus maze, where anxiogenic effects at low doses and anxiolytic effects at high doses were reported (Lin et al., 1999). Our data showing anxiogenic-like and anti-aggressive effects of MDMA are in agreement with several previous works performed in various animal models including a mouse elevated plus maze (Navarro and Maldonado, 2002) and a light–dark box (Maldonado and Navarro, 2000), and in mouse agonistic behavior models (Maldonado and Navarro, 2001; Navarro and Maldonado, 1999; Navarro et al., 2004). Although in the latter work, there a lower dosing regimen was used (1.25–5.0 mg/kg) than in ours (2.5–30.0 mg/kg), it is important to take into account that authors evaluated mouse behavior exhibited in social interactions between isolated males and anosmic partners, which definitely presented different stimuli than our group-housed naive partners.
Acute behavioural and neurotoxic effects of MDMA plus cocaine in adolescent mice
2009, Neurotoxicology and Teratology
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Corresponding author. José Francisco Navarro, Department of Psychobiology, Faculty of Psychology, Campus de Teatinos, University of Malaga, 29071 Málaga, Spain. Email: [email protected]