Regular PaperRegulation of angiogenesis by SPARC and angiostatin: implications for tumor cell biology
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The development of human serum albumin-based drugs and relevant fusion proteins for cancer therapy
2021, International Journal of Biological MacromoleculesCitation Excerpt :Then, the caveolae transport the Gp60-bound HSA, free HSA and HSA-bound drugs across the endothelium, and release them from the basolateral membrane into the extracellular interstitium [10]. SPARC, secreted protein, acidic and rich in cysteine, also termed as osteonectin or basement membrane 40 (BM40), is a secreted glycoprotein that can bind with some kinds of proteins including albumins, and mainly functions in mediating the cell-extracellular environment interactions during the process of morphogenesis, tissue remodeling and angiogenesis [11,12]. Subsequently, HSA-based drugs can bind to SPARC which is highly expressed in a variety of tumors and accumulate in the tumor interstitium.
Secreted protein acidic and rich in cysteine (SPARC) regulates thermogenesis in white and brown adipocytes
2020, Molecular and Cellular EndocrinologyNatural remedies and functional foods as angiogenesis modulators
2020, Functional Foods in Cancer Prevention and TherapySPARC expression in desmoplastic and non desmoplastic pancreatic carcinoma and cholangiocarcinoma
2019, Pathology Research and PracticeCitation Excerpt :However, in this study we did not examined this perspective. It was previously hypothesized that SPARC possibly acts by suppressing the angiogenesis factors, as VEGF and platelet-derived growth factors [30–32]. The role of SPARC in inhibiting the synthesis and secretion of VEGF has also been reported in gliomas [33].
Unraveling the Function of Skeletal Muscle as a Secretory Organ: Role of Myokines on Muscle Regulation
2018, Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength