Abstract
Pain-depressed behavior can be defined as any behavior that decreases in rate, frequency, duration, or intensity in response to a putative pain state. Common examples include pain-related decreases in feeding, locomotion and expression of positively reinforced operant behavior. In humans, depression of behavior is often accompanied by a comorbid depression of mood. Measurements of pain-depressed behaviors are used to diagnose pain in both human and veterinary medicine, and restoration of pain-depressed behavior is often a priority of treatment. This article describes two strategies for integrating measures of pain-depressed behaviors into preclinical assays of pain and analgesia. Assays of pain-depressed behaviors may contribute both to improved translational efficiency in analgesic drug development and to new insights regarding the mechanisms and determinants of pain and analgesia.
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Blackburn-Munro G (2004) Pain-like behaviours in animals - how human are they? Trends Pharmacol Sci 25:299–305
Mogil JS, Crager SE (2004) What should we be measuring in behavioral studies of chronic pain in animals? Pain 112:12–15
Negus SS, Vanderah TW, Brandt MR, Bilsky EJ, Becerra L, Borsook D (2006) Preclinical assessment of candidate analgesic drugs: recent advances and future challenges. J Pharmacol Exp Ther 319:507–514
Vierck CJ, Hansson PT, Yezierski RP (2008) Clinical and pre-clinical pain assessment: are we measuring the same thing? Pain 135:7–10
Whiteside GT, Adedoyin A, Leventhal L (2008) Predictive validity of animal pain models? A comparison of the pharmacokinetic-pharmacodynamic relationship for pain drugs in rats and humans. Neuropharmacology 54:767–775
Stevenson GW, Bilsky EJ, Negus SS (2006) Targeting pain-suppressed behaviors in preclinical assays of pain and analgesia: effects of morphine on acetic acid-suppressed feeding in C57BL/6J mice. J Pain 7:408–416
Gracely RH, Petzke F, Wolf JM, Clauw DJ (2002) Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum 46:1333–1343
Skljarevski V, Ramadan NM (2002) The nociceptive flexion reflex in humans - review article. Pain 96:3–8
Price DD (2000) Psychological and neural mechanisms of the affective dimension of pain. Science 288:1769–1772
Price DD (2002) Central neural mechanisms that interrelate sensory and affective dimensions of pain. Mol Interv 2:392–402
Martin TJ, Buechler NL, Kahn W, Crews JC, Eisenach JC (2004) Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain. Anesthesiology 101:191–203
Matson DJ, Broom DC, Carson SR, Baldassari J, Kehne J, Cortright DN (2007) Inflammation-induced reduction of spontaneous activity by adjuvant: a novel model to study the effect of analgesics in rats. J Pharmacol Exp Ther 320:194–201
Morgan D, Carter CS, Dupree JP, Yezierski RP, Vierck CJ (2008) Evaluation of prescription opioids using operant-based pain measures in rats. Exp Clin Psychopharmacol 16:367–375
Pereira Do Carmo G, Stevenson GW, Carlezon WA Jr, Negus SS (2009) Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behavior. Pain 144:170–177
Reid LD (1987) Tests involving pressing for intracranial stimulation as an early procedure for screening the likelihood of addiction of opioids and other drugs. In: Bozarth MJ (ed) Methods of assessing the reinforcing properties of abused drugs. Springer, Berlin, pp 391–420
Roeska K, Doods H, Arndt K, Treede RD, Ceci A (2008) Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. Pain 139:349–357
Bair MJ, Robinson RL, Katon W, Kroenke K (2003) Depression and pain comorbidity: a literature review. Arch Intern Med 163:2433–2445
Gureje O, Von Korff M, Kola L, Demyttenaere K, He Y, Posada-Villa J, Lepine JP, Angermeyer MC, Levinson D, de Girolamo G, Iwata N, Karam A, Guimaraes Borges GL, de Graaf R, Browne MO, Stein DJ, Haro JM, Bromet EJ, Kessler RC, Alonso J (2008) The relation between multiple pains and mental disorders: results from the World Mental Health Surveys. Pain 135:82–91
Jann MW, Slade JH (2007) Antidepressant agents for the treatment of chronic pain and depression. Pharmacotherapy 27:1571–1587
Lepine JP, Briley M (2004) The epidemiology of pain in depression. Hum Psychopharmacol 19(Suppl. 1):S3-S7
Cleeland CS, Ryan KM (1994) Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singapore 23:129–138
Dworkin RH, Turk DC, Wyrwich KW, Beaton D, Cleeland CS, Farrar JT, Haythornthwaite JA, Jensen MP, Kerns RD, Ader DN, Brandenburg N, Burke LB, Cella D, Chandler J, Cowan P, Dimitrova R, Dionne R, Hertz S, Jadad AR, Katz NP, Kehlet H, Kramer LD, Manning DC, McCormick C, McDermott MP, McQuay HJ, Patel S, Porter L, Quessy S, Rappaport BA, Rauschkolb C, Revicki DA, Rothman M, Schmader KE, Stacey BR, Stauffer JW, von Stein T, White RE, Witter J, Zavisic S (2008) Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. J Pain 9:105–121
Kerns RD, Turk DC, Rudy TE (1985) The West Haven-Yale Multidimensional Pain Inventory (WHYMPI). Pain 23:345–356
National Research Council (1996) Guide for the care and use of laboratory animals. National Academy Press, Washington, DC
Carlezon WA Jr, Chartoff EH (2007) Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation. Nat Protoc 2:2987–2995
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Negus, S.S., Bilsky, E.J., Carmo, G.P.D., Stevenson, G.W. (2010). Rationale and Methods for Assessment of Pain-Depressed Behavior in Preclinical Assays of Pain and Analgesia. In: Szallasi, A. (eds) Analgesia. Methods in Molecular Biology, vol 617. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-323-7_7
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DOI: https://doi.org/10.1007/978-1-60327-323-7_7
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