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Hypotensive effect of eledoisin, physalaemin and related peptides in man

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Summary

Eledoisin, physalaemin, and 29 synthetic polypeptides related to eledoisin and physalaemin were screened for their hypotensive effect in man.

Experiments demonstrated that it was possible to modify the eledoisin and physalaemin molecules without any strong reduction of activity.

Influence of structural variations on hypotensive effect is discussed.

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References

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Author information

Authors and Affiliations

  1. Institute of Pharmacology and Department of Medical Pathology, University of Parma, Parma, Italy

    Giuseppe de Caro, Leopoldo Farruggia, Ermanno Minardi & Almerico Novarini

Authors
  1. Giuseppe de Caro
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  2. Leopoldo Farruggia
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  3. Ermanno Minardi
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  4. Almerico Novarini
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Additional information

This work was supported by a grant from the Consiglio Nazionale delle Ricerche, Rome.

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de Caro, G., Farruggia, L., Minardi, E. et al. Hypotensive effect of eledoisin, physalaemin and related peptides in man. Naunyn-Schmiedebergs Arch. Pharmak. u. Exp. Path. 254, 194–198 (1966). https://doi.org/10.1007/BF00535905

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  • DOI: https://doi.org/10.1007/BF00535905

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