Summary
Oral contraceptive steroids increased the residence time of caffeine in 9 young women by a factor of 2. The effect was already manifested during the first cycle 2 weeks after starting oral contraceptive steroids (OCS) and was slightly increased in the second cycle, after 6 weeks on OCS. Toxic effects attributed to oral contraceptive steroids may in part be indirect and due to prolonged retention of absorbed toxic agents to which women are exposed.
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Rietveld, E.C., Broekman, M.M.M., Houben, J.J.G. et al. Rapid onset of an increase in caffeine residence time in young women due to oral contraceptive steroids. Eur J Clin Pharmacol 26, 371–373 (1984). https://doi.org/10.1007/BF00548769
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DOI: https://doi.org/10.1007/BF00548769