Summary
The effect of val5-angiotensin II on steady-state sodium concentration gradients (ΔcNa) was studied in rat proximal tubules by stationary micro-perfusion combined with perfusion of the peritubular capillaries. Angiotensin added to the peritubular perfusion fluid had a biphasic action with stimulation of sodium reabsorption at low doses (10−12–10−10 M) and inhibition at high doses (3×10−7–3×10−6 M). Stimulation of transport was also observed with intraluminal angiotensin but only at a dose of 10−9M. Transepithelial potential difference was calculated from the steady-state chloride distribution; no significant change was observed at low (10−11M) or high (10−6M) concentrations and a direct action on sodium transport is postulated. This biphasic effect is discussed in relation to the responses of the intact kidney to intra-renal infusion of angiotensin, and to the control of tubulo-glomerular feed-back.
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References
Barraclough, M. A., Jones, N. F., and Marsden, C. D.: Effect of angiotensin on renal function in the rat. Amer. J. Physiol.212, 1153–1157 (1967)
Bolton, J. E., Munday, K. A., Murley, C., Parsons, B. J. and Poat, J. A.: The relationship between plasma angiotensin II concentrations and fluid transport by rat jejunumin vivo. J. Physiol. (Lond.)254, 81–82P (1976)
Bolton, J. E., Munday, K. A., Parsons, B. J. and Poat, J. A.: Effects of angiotensin on fluid transport by rat jejunumin vivo. J. Physiol. (Lond.)241, 33–34P (1974)
Davies, N. T., Munday, K. A. and Parsons, B. J.: The effect of angiotensin on rat intestinal fluid transfer. J. Endocr.48, 39–46 (1970)
Győry, A. Z., Lingard, J. M. and Young, J. A.: Relation between active sodium transport and distance along teh proximal convolution of rat nephrons: evidence for homogeneity of sodium transport. Pflügers Arch.348, 205–210 (1974)
Hayden, L. J., Shagrin, J. M. and Young, J. A.: Micropuncture investigation of the anion content of colloid from single rat thyroid follicles. A micromethod for the simultaneous determination of iodide and chloride in nanomole quantities. Pflügers Arch.321, 173–186 (1970)
Hornych, A., Meyer, P. and Milliez, P.: Angiotensin, vasopressin and cyclic AMP: effects on sodium and water fluxes in rat colon. Amer. J. Physiol.224, 1223–1229 (1973)
Navar, L. G. and Langford, H. G.: Effects of angiotensin on the renal circulation. In: Angiotensin.Handbuch der exp. Pharmakol. Bd. 37, 445–474. Berlin-Heidelberg-New York: Springer 1974
Oster, P., Hackenthal, E., and Hepp, R.: Radioimmunoassay of angiotensin II in rat plasma. Experientia29, 353–354 (1973)
Steven, K.: Effect of peritubular infusion of angiotensin II on rat proximal nephron function. Kidney Int.6, 73–80 (1974)
Thurau, K.: Intrarenal action of angiotensin. In: Angiotensin.Handbuch der exp. Pharmakol. Bd. 37, 475–489. Berlin-Heidelberg-New York: Springer 1974
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Harris, P.J., Young, J.A. Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin II in the rat kidney. Pflugers Arch. 367, 295–297 (1977). https://doi.org/10.1007/BF00581370
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DOI: https://doi.org/10.1007/BF00581370