Abstract
α-Melanocyte stimulating hormone (α-MSH), a 13 amino acid neuropeptide produced by the pituitary gland, was found to markedly inhibit the capacity of exogenously administered interleukin-1 (IL-1) to stimulate the enhanced synthesis of acute-phase proteins and induce neutrophilia in vivo. The administration of ACTH or glucocorticosteroids lacked most of these direct IL-1 inhibitory properties. Therefore, in addition to the previously reported antipyretic action of α-MSH, this hormone can also inhibit two other known IL-1-sensitive cellular targets in vivo. Further, α-MSH was incapable of modifying the comitogenic influence of IL-1 on murine thymocytes or on an IL-1 responsive T-cell line. These findings suggest a target cell specificity to the IL-1 inhibitory activities of α-MSH and fail to support the hypothesis that α-MSH functions through competitive inhibition of specific cellular receptors for IL-1.
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Robertson, B.A., Gahring, L.C. & Daynes, R.A. Neuropeptide regulation of interleukin-1 activities. Inflammation 10, 371–385 (1986). https://doi.org/10.1007/BF00915821
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DOI: https://doi.org/10.1007/BF00915821