Abstract
Angiotensin converting enzyme (ACE) has multiple effects both as the enzyme which cleaves angiotensin II from angiotensin I and as that which breaks down bradykinin. The present study examines ACE mRNA and protein expression in the rat kidney during development. Changes in distribution and expression during development are consistent with suggestions that the renin angiotensin system is important in growth modulation, vascular development and regulation, and protein reabsorption.
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Lynch KR, Simnad VI, Ben-Ari ET, Garrison JC (1986) Localization of preangiotensinogen mRNA sequences in the rat brain. Hypertension 8: 540–543
Gomez RA, Chevalier RV, Carey RM, Peach MJ (1990) Molecular biology of the renin-angiotensin system. Kidney Int 38 [Suppl 30]: S18-S23
Lilly LS, Pratt RE, Alexander RW, Larson DM, Ellison KE, Gimbrone MA, Dzau VJ (1985) Renin expression by vascular endothelial cells in culture. Circ Res 57: 312–318
Dzau VJ, Kreisberg J (1986) Cultured glomerular mesangial cells contain renin: influence of calcium and isoproterenol. J Cardiovasc Pharmacol 8 [Suppl 8]: S6-S10
Levens NR, Peach MJ, Carey RM (1981) Role of the intrarenal renin-angiotensin system in the control of renal function. Circ Res 4: 157–167
Navar LG, Rosivall L (1984) Contribution of the renin-angiotensin system to the control of intrarenal hemodynamics. Kidney Int 25: 857–868
Dzau VJ (1989) Multiple pathways of angiotensin production in the blood vessel wall: evidence, possibilities and hypotheses J Hypertens 7: 933–936
Ehlers MRW, Riordan JF (1989) Angiotensin-converting enzyme: new concepts concerning its biological role. Biochemistry 28: 5311–5318
Ehlers MRW, Riordan JF (1990) Angiotensin converting enzyme: biochemistry and molecular biology. In: Laragh JH, Brenner BM (eds) Hypertension: pathophysiology, diagnosis and management. Raven, New York, pp 1217–1231
Hilbert P, Lindpaintner K, Beckmann JS, Serikawa T, Soubrier F, Dubay C, Cartwright P, De Gouyon B, Julier C, Takahasi S, Vincent M, Ganten D, Georges M, Lathrop GM (1991) Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 353: 521–529
Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao Y-P, Dzau VJ, Lander E (1991)Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 67: 213–224
Krieger JE, Mukoyama M, Koike G, Jacob H, Yee G, Lander E, Lawn R, Pratt RE, Dzau VJ (1992) Evidence for mutation in the promotor region of the ACE gene of SHR-SP vs WKY rats (abstract). Hypertension 20: 450
Gomez RA, Lynch KR, Sturgill BC, Elwood JP, Chevalier RL, Carey RM, Peach MJ (1989) Distribution of renin mRNA and its protein in the developing kidney. Am J Physiol 257: F850-F858
Herrmann HC, Dzau VJ (1983) Feedback regulation of angiotensinogen production by components of the renin-angiotensinogen system. Circ Res 52: 328–334
Haber E, Koerner T, Page LB, Kliman B, Purnode A (1969) Application of radioimmunoassay for angiotensin I to the physiologic measurement of plasma renin activity in the normal human subject. J Clin Endocrinol Metab 29: 1349–1355
Cushman DW, Cheung HS (1971) Concentration of angiotensin converting enzyme in tissues of the rat. Biochim Biophys Acta 250: 261–265
Cushman DW, Wang FL, Fung WC, Harfey CM, DeForrest JM (1989) Differentiation of angiotensin-converting enzyme (ACE) inhibitors by their selective inhibition of ACE in physiologically important target organs. Am J Hypertens 2: 294–306
Avreamas S (1969) Enzyme markers: their linkage with proteins and use in immunohistochemistry. Histochem J 4: 321–330
Conroy J, Hoffman H, Kirk ES, Hirzl HO, Sonnenblick EH, Soffer RL (1976) Pulmonary angiotensin-converting enzyme: interspecies homology and inhibition by heterologous antibody in vivo. J Biol Chem 251: 4828–4832
Ingelfinger JR, Zuo WM, Fon TE, Ellison KE, Dzau VJ (1990) In situ hybridization localization of the intrarenal angiotensinogen: an hypothesis for the intrarenal renin angiotensin system. J Clin Invest 85: 417–422
Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G, Corvol P (1988) Two putative active centers in human angiotensin I converting enzyme revealed by molecular cloning. Proc Natl Acad Sci USA 85: 9386–9390
Glisin V, Crkvenjakov R, Byus C (1974) Ribonucleic acid isolated by cesium chloride centrifugation. Biochemistry 13: 2633–2637
Thomas PD (1980) Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose Proc Natl Acad Sci USA 77: 5201–5205
Mounier F, Hinglais N, Sich M, Gros F, Lacoste M, Deris Y, Alhenc-Gelas F, Gubler M-C (1987) Ontogenesis of angiotensin-I converting enzyme in human kidney. Kidney Int 32: 684–690
Wallace KB, Bailie MD, Hook JB (1978) Angiotensin-converting enzyme in developing lung and kidney. Am J Physiol 234: R141-R145
Wigger HJ, Stalcup SA (1978) Distribution and development of angiotensin converting enzyme in the fetal and newborn rabbit. An immunofluorescence study. Lab Invest 38: 581–585
Taugner R, Hackenthal F, Rix E, Nobiling R, Paulsen K (1982) Immunohistochemistry of the renin-angiotensin system. Kidney Int 22 [Suppl 12]: S33-S43
Richoux JP, Cordonnier JL, Bouhnik J, Clauser E, Corvol P, Menard J, Grignon G (1983) Immunochemical localization of angiotensinogen in rat liver and kidney. Cell Tissue Res 233: 439–451
Caldwell PR, Seegal BC, Hsu KC, Das M, Soffer RL (1976) Angiotensin-converting enzyme: vascular endothelial localization. Science 191: 1050–1051
Bruneval P, Hinglais N, Alhenc-Gelas F, Tricottet V, Corvol P, Menard J, Camilleri JP, Bariety J (1986) Angiotensin I converting enzyme in human intestine and kidney: ultrastructural immunohistochemical localization. Histochemistry 85: 73–80
Fukatsu A, Yuzawa Y, Niesen N, Matsuo S, Caldwell PRB, Brentjens JRB, Andres G (1988) Local formation of immune deposits in rabbit proximal tubules. Kidney Int 34: 611–619
Yanagawa N, Capparelli AW, Jo OD, Briedal A, Barrett JD, Eggena P (1991) Production of angiotensinogen and renin-like activith by rabbit proximal tubular cells in culture. Kidney Int 39: 938–941
Ujiie K, Moe OW, Miller RT, Alpern RJ, Henrich WL, Star RA (1992) Regulated expression of renin mRNA in rat proximal tubules (abstract). J Am Soc Nephrol 3: 448
Deschepper CF, Mellon SH, Cumin F, Baxter JD, Ganong WF (1986) Analysis by immunohistochemistry and in situ hybridization of renin and its mRNA in kidney, testis, adrenal, and pituitary of the rat. Proc Natl Acad Sci USA 83: 7552–7556
Leyssac PP (1986) Changes in single nephron renin release are mediated by tubular flow rate. Kidney Int 30: 332–339
Douglas JG (1988) Angiotensin effects on phospholipase A2 in proximal tubular epithelium are mediated by a GTP binding protein. Kidney Int 33: 154A
Douglas JG, Romero M, Hopfer U (1990) Signaling mechanisms coupled to the angiotensin receptor of proximal tubular epithelium. Kidney Int 38 [Suppl 30]: S43-S47
Grady EF, Sechi LA, Griffen CA, Schambelan M, Kalinyak JE (1991) Expression of AT2 receptors in the developing rat fetus. J Clin Invest 88: 921–933
Seikaly MG, Arant BS Jr, Seney FD Jr (1990) Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest 86: 1352–1357
Liu F-Y, Cogan MG (1987) Angiotensin II: a potent regulator of acidification in the rat early proximal convoluted tubule J Clin Invest 30: 272–275
Liu F-Y, Cogan MG (1988) Angiotensin II stimulation of hydrogen ion secretion in the rat early proximal tubule. Modes of action, mechanism, and kinetics. J Clin Invest 82: 601–607
Schuster VL, Kokko JP, Jacobson HF (1984) Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules. J Clin Invest 73: 507–515
Harris PJ, Navar LG (1985) Tubular transport responses to angiotensin. Am J Physiol 284: F621-F630
Harris PJ, Young JA (1977) Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin II in the rat kidney. Pflugers Arch 367: 295–297
Fine L, Badie-Dezfooly B, Chaudhari A (1985) Angiotensin II induces hypertrophy of renal proximal tubular cells. Clin Res 33: 584A
Wolf G, Neilson EG (1990) Angiotensin II induces cellular hypertrophy in a murine proximal tubular cell line Am J Physiol 259: F768-F777
Norman J, Badie-Dezfooly B, Nord EP, Kurtz I, Schlosser J, Chaudhari A, Fine LG (1987) EGF-induced mitogenesis in proximal tubular cells; potentiation by angiotensin II. Am J Physiol 253: F299-F309
Wolf G, Neilson EG (1992) Effects of angiotensin II on proximal tubular cells stably transfected with the c-mas oncogene. Am J Physiol 163: F931-F938
Defendini R, Zimmerman EA, Weare JA, Alhenc-Gelas F, Erdos EG (1983) Angiotensin-converting enzyme in epithelial and neuroepithelial cells. Neuroendocrinology 37: 32–40
Stewart TA, Weare JA, Erdos EG (1981) Purification and characterization of human converting enzyme (kininase II). Peptides 2: 145–152
Skidgel RA, Engelbrecht S, Johnson AR, Erdos EG (1984) Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase. Peptides 5: 769–776
Carone FA, Peterson DR, Flouret G (1982) Renal tubular processing of small peptide hormones. J Lab Clin Med 100: 1–14
Duggan KA, Mendelsohn FAO, Levens N (1989) Angiotensin receptors and angiotensin I-converting enzyme in rat intensine. Am J Physiol 253: G781-G786
Yoshioka M, Erickson RH, Woodley JF, Gulli R, Guan D, Kim YS (1987) Role of rat intestinal brush border membrane angiotensin converting enzyme in dietary protein digestion. Am J Physiol 253: G781-G786
Ingelfinger JR, Anderson S, Hirsch A, Bouyounes B, Brenner BM (1990) Renal angiotensin converting enzyme (ACE) activity is related to degree of proteinuria in active puromycin nephrosis (PAN). Pediatr Res 27: 330A
Arevalo AE, Ibarro-Rubio ME, Cruz C, Pedraza-Chaverri J, Pena JC (1990) Angiotensin converting enzyme (ACE) in serum, urine and tissues from nephrotic rats (abstract). J Am Soc Nephrol 1: 606
Bruneval P, Hinglais J, Camilleri JP, Bariety J (1986) Angiotensin I converting enzyme in human small intestine and kidney. Characterization by immunofluorescence and ultra structural immunohistochemistry. Histochemistry 85: 73–80
Takada Y, Hiwada K, Unno M, Kokubo T (1982) Immunocytochemical localization of angiotensin converting enzyme at the ultrastructural level in the human lung and kidney. Biomed Res 3: 169–174
Takada Y, Unno M, Hiwada K, Kokubu T (1981) Immunological and immunofluorescent studies of human angiotensin-converting enzyme. Clin Sci 61 [Suppl 7]: 253S-256S
Caldwell PR, Seegal BC, Hsu KC, Das M, Soffer RL (1976) Angiotensin-converting enzyme: vascular endothelial localization: Science 191: 1050–1051
Hall ER, Kato J, Erdos ECT, Robinson CJG, Oshima G (1976) Angiotensin I-converting enzyme in the nephron. Life Sci 18: 1299–1304
Danilov SM, Faerman AI, Printseva OY, Martynov AV, Sakharov IY, Trakht IN (1987) Immunohistochemical study of angiotensin converting enzyme in human tissues using monoclonal antibodies. Histochemistry 87: 487–490
Hunt MK, Ramos SP, Geary KM, Norling LL, Peach MJ, Gomez RA, Carey RM (1992) Colocalization and release of angiotensin and renin in renal cortical cells. Am J Physiol 263: F363-F373
Deschepper CF, Mellon SH, Cumin F, Baxter JD, Ganong WF (1986). Analysis by immunohistochemistry and in situ hybridization of renin and its mRNA in kidney, testis, adrenal, and pituitary of the rat. Proc Natl Acad Sci USA 83: 7552–7556
Dzau VJ, Kreisberg J (1986) Cultured glomerular cells contain renin: influence of calcium and isoproterenol. J Cardiovasc Pharmacol 8 [Suppl 8]: S6-S10
Inagami T, Kawamura M, Naruse K, Okamura T (1986) Localization of components of the renin-angiotensin system within the kidney. Fed Proc 45: 1414–1419
Tufro-McReddie AS, Harrison JR, Everett AD, Gomez RA (1993) Ontogeny of type 1 angiotensin II receptor gene expression in the rat. J Clin Invest 91: 530–537
Haley DP, Sarrafian M, Bulger RE, Dobyan DC, Eknoyan G (1987) Structural and functional correlates of effects of angiotensin-induced changes in rat glomerulus. Am J Physiol 253: F111-F119
Kastner PR, Hall JE, Guyton AC (1984) Control of glomerular filtration rate: role of intrarenally formed angiotensin II. Am J Physiol 146: F897-F906
Andrews PM (1981) Investigations of cytoplasmic contractile and cytoskeletal elements in the kidney glomerulus. Kidney Int 20: 549–562
Ausiello DA, Kreisberg JI, Roy C, Karnovsky JM (1980) Contraction of cultured rat glomerular cells of apparent mesangial origin after stimulation with angiotensin and arginine-vasopressin. J Clin Invest 65: 754–760
Foidart J, Sraer J, Delarue F, Mahieu P, Ardaillou R (1980) Evidence for mesangial glomerular receptors for angiotensin II linked to mesangial cell contractility. FEBS Lett 121: 333–336
Osborne MJ, Droz B, Meyer P, Morel F (1975) Angiotensin II: renal localization in glomerular mesangial cells by autoradiography. Kidney Int 8: 245–254
Gibbons GH, Pratt RE, Dzau VJ (1992) Vascular smooth muscle cell hypertrophy vs. hyperplasia. J Clin Invest 90: 456–461
Itoh H, Pratt RE, Dzau VJ (1990) Antisense oligonucleotides complementary to PDGF mRNA attenuate angiotensin II-induced hypertrophy (abstract). Hypertension 16: 325
Gibbons GH, Pratt RE, Dzau VJ (1989) Angiotensin II is a bifunctional vascular smooth muscle cell growth factor. Hypertension 14: 358a
Owens GK, Geisterfer AAT, Yang W-H, Komoriya A (1988) Transforming growth factor beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells. J Cell Biol 107: 771–780
Faubert PF, Chou SY, Porush JG (1987) Regulation of papillary plasma flow by angiotersin II. Kidney Int 32: 472–478
Chou SY, Faubert PF, Porush JF (1986) Contribution of angiotensin to the control of medullary hemodynamics. Fed Proc 45: 1438–1443
Mendelsohn FAO, Dunbar M, Allen A, Chou ST, Millan MA, Aguilera G, Catt KJ (1986) Angiotensin II receptors in the kidney. Fed Proc 45: 1420–1425
Robillard JE, Gomez RA, VanOrden D, Smith FG (1982) Comparison of the adrenal and renal responses to angiotensin II in fetal lambs and adult sheep. Circ Res 50: 140
Drukker A, Goldsmith DI, Spitzer A, Edelmann CM, Blaufox MD (1980) The renin angiotensin system in newborn dogs: developmental patterns and response to acute saline loading. Pediatr Res 14: 304–307
Bailie MD, Osborn JL, Hook JB (1973) Effect of inhibition of prostaglandin synthetase and angiotensin II on renal function in the newborn piglet. In: Spitzer A (ed) The kidney during development: morphology and function. Masson, New York, pp 173–181
Robillard JE (1970) Changes in renal vascular reactivity to angiotensin II during development in fetal, newborn and adult sheep: role of A-II vascular receptors occupancy. Pediatr Res 17: 355A
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Jung, F.F., Bouyounes, B., Barrio, R. et al. Angiotensin converting enzyme in renal ontogeny: hypothesis for multiple roles. Pediatr Nephrol 7, 834–840 (1993). https://doi.org/10.1007/BF01213370
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DOI: https://doi.org/10.1007/BF01213370