Summary
Halothane anesthesia was found to be hepatotoxic in the rat, as demonstrated by a significant elevation of serum xanthine oxidase (SXO) level. SXO appeared to be a more sensitive marker of liver damage than serum, glutamic oxalacetic transaminsa. SXO was found to be elevated also following exposure to relative hypoxia.
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Giler, S., Ventura, E., Levy, E. et al. Elevation of serum xanthine oxidase following halothane anesthesia in the rat. Experientia 32, 620–621 (1976). https://doi.org/10.1007/BF01990198
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DOI: https://doi.org/10.1007/BF01990198