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Induction of vascular smooth muscle bradykinin B1 receptorsin vivo during antigen arthritis

  • Non-Rheumatic Inflammatory Diseases
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Abstract

Antigen arthritis in rabbits was associated with induction of bradykinin B1 receptors in isolated aorta smooth muscle 24 h following intra-articular injection of antigen in sensitized animals. Control tissues developed responsiveness to desArg9-bradykinin or bradykinin during 3 h incubation, but failed to respond to either kinin at the beginning of experiments. Aorta from rabbits 24 h after induction of arthritis not only developed responsiveness to kinins more rapidly than controls, but also responded at the outset of experiments. Antigen arthritis was characterized by acute phase protein synthesis and joint swelling. This is the first demonstration of induction of smooth muscle responsiveness to desArg9-bradykinin during an immune complex disease.

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References

  1. S. G. Farmer and R. M. Burch,The pharmacology of bradykinin receptors. InBradykinin Antagonists: Basic and Clinical Research. (Ed. R. M. Burch) pp. 1–31, Marcel Dekker Inc., New York 1990.

    Google Scholar 

  2. F. Marceau, A. Lussier, D. Regoli and J. P. Giroud,Pharmacology of kinins: their relevance to tissue injury and inflammation. Gen. Pharmacol.14, 209–229 (1983).

    PubMed  Google Scholar 

  3. J. Bouthillier, D. Deblois, and F. Marceau,Studies on the induction of pharmacological responses to des-Arg 9-bradykinin in vitro and in vivo. Br. J. Pharmacol.92, 257–264 (1987).

    PubMed  Google Scholar 

  4. R. Couture, J. Mizrahi, D. Regoli and G. Devroede,Peptides and the human colon: an in vitro pharmacological study. Can. J. Physiol. Pharmacol.59, 957–970 (1982).

    Google Scholar 

  5. F. Marceau, J. Barabé, S. St. Pierre and D. Regoli,Kinin receptors in experimental inflammation. Can. J. Physiol. Pharmacol.58, 536–542 (1980).

    PubMed  Google Scholar 

  6. D. Deblois, J. Bouthillier and F. Marceau,Effect of glucocorticoids, monokines and growth factors on the spontaneously developing responses of the rabbit isolated aorta to des Arg 9 bradykinin. Br. J. Pharmacol.93, 969–977 (1988).

    PubMed  Google Scholar 

  7. D. Regoli, F. Marceau and J. Lavigne,Induction of B 1 receptors for kinins in the rabbit by a bacterial lipopolysaccharide. Eur. J. Pharmacol.71, 105–115 (1981).

    Article  PubMed  Google Scholar 

  8. M. Martin and K. Resch,Interleukin 1: more than a mediator between leukocytes. Trends Pharmacol. Sci.9, 171–177 (1988).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Nova Pharmaceutical Corporation, 6200 Freeport Centre, 21224-2788, Baltimore, MD, USA

    S. G. Farmer, B. A. McMillan, S. N. Meeker & R. M. Burch

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  1. S. G. Farmer
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  2. B. A. McMillan
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  3. S. N. Meeker
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  4. R. M. Burch
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Farmer, S.G., McMillan, B.A., Meeker, S.N. et al. Induction of vascular smooth muscle bradykinin B1 receptorsin vivo during antigen arthritis. Agents and Actions 34, 191–193 (1991). https://doi.org/10.1007/BF01993275

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  • DOI: https://doi.org/10.1007/BF01993275

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