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Menstrual cycle effects on caffeine elimination in the human female

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Summary

Increases in the levels of sex steroids due to pregnancy or oral contraceptive steroid use are known to decrease significantly the rate at which caffeine is eliminated from the body. An investigation has now been made into whether the changes in sex steroid levels that occur during normal menstrual cycling also affect the rate of caffeine elimination, especially whether hormonal shifts in the luteal phase are associated with slower elimination of caffeine. Repeated 24-hour caffeine elimination studies were conducted during the follicular and luteal phases of the menstrual cycle in 10 healthy women.

Comparisons of the follicular and luteal phases revealed that systemic clearance of caffeine was slower in the luteal phase, although the t1,2 did not differ. The slowing effect was related to the proximity to onset of menstruation and to levels of progesterone.

The evidence suggests that caffeine elimination may be slowed in the late luteal phase, prior to the onset of menstruation. Such a reduction would lead to increased accumulation of caffeine with repeated self-administration during the day, but the effect may be too small to be of clinical significance in the majority of women.

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References

  1. Barone JJ, Roberts H (1984) Human consumption of caffeine. In: Dews PB (ed) Caffeine. Springer, Berlin Heidelberg New York, pp 59–73

    Google Scholar 

  2. Greden JF (1974) Anxiety or caffeinism: a diagnostic dilemma. Am J Psychiatry 131: 1089–1092

    Google Scholar 

  3. American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders, 3rd ed, revised. Washington, DC, pp 138–139

  4. Patwardhan RV, Desmond PV, Wilkinson GR, Schenker S (1980) Impaired elimination of caffeine by oral contraceptive steroids. J Lab Clin Med 95: 604–608

    Google Scholar 

  5. Callahan MM, Robertson RS, Branfman AR, McComish MF, Yesair DW (1983) Comparison of caffeine metabolism in three nonsmoking populations after oral administration of radiolabeled caffeine. Drug Metab Dispos 11: 211–217

    Google Scholar 

  6. Reitveld EC, Brockman MMM, Houben JJG, Eskes TKAB, van Rossum JM (1984) Rapid onset of an increase in caffeine residence time in young women due to oral contraceptive steroids. Eur J Clin Pharmacol 26: 371–373

    Google Scholar 

  7. Abernethy DR, Todd EL (1985) Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol 28: 425–428

    Google Scholar 

  8. Aldridge A, Bailey J, Neims AH (1981) The disposition of caffeine during and after pregnancy. Semin Perinatol 5: 310–314

    Google Scholar 

  9. Cook CE, Tallent CR, Amerson E, Myers MW, Kepler JA, Taylor GC, Christensen HD (1976) Caffeine in salvia and plasma by a radioimmune assay procedure. J Pharmacol Exp Ther 199: 679–686

    Google Scholar 

  10. Neims AH, von Borstel RW (1983) Caffeine: metabolism and biochemical mechanisms of action. In: Wurtman RJ, Wurtman JJ (eds) Nutrition and the brain, vol 6. Raven Press, New York, pp 1–29

    Google Scholar 

  11. Balogh A, Irmisch E, Klinger G, Splinter FK, Hoffmann A (1987) Untersuchungen zur Elimination von Coffein und Metamizol im Menstruationszyklus der fertilen Fran. Zentralbl Gynä-kol 109: 1135–1142

    Google Scholar 

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Lane, J.D., Steege, J.F., Rupp, S.L. et al. Menstrual cycle effects on caffeine elimination in the human female. Eur J Clin Pharmacol 43, 543–546 (1992). https://doi.org/10.1007/BF02285099

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  • DOI: https://doi.org/10.1007/BF02285099

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